Savasta M, Dubois A, Feuerstein C, Manier M, Scatton B
Neurosci Lett. 1987 Feb 24;74(2):180-6. doi: 10.1016/0304-3940(87)90146-7.
The precise topographical changes in striatal D2 dopamine receptors that occur after neurotoxic lesion of the mesostriatal dopaminergic pathway have been studied autoradiographically in the rat through the use of [3H]spiperone as a ligand. 6-Hydroxydopamine-induced lesion of the dopaminergic afferents to the striatum caused an increase in [3H]spiperone binding in the ventro- and dorsolateral but not in the ventro- and dorsomedian aspects of the striatum. This lesion caused a loss of tyrosine hydroxylase-like immunoreactivity in all striatal subregions. These results demonstrate that not all striatal D2 dopamine receptors are able to proliferate after dopaminergic denervation.
通过使用[3H]司来吉兰作为配体，利用放射自显影技术在大鼠中研究了中脑纹状体多巴胺能通路神经毒性损伤后纹状体D2多巴胺受体发生的精确地形学变化。6-羟基多巴胺诱导的纹状体多巴胺能传入神经损伤导致纹状体腹侧和背外侧[3H]司来吉兰结合增加，但纹状体腹侧和背内侧部分未增加。该损伤导致所有纹状体亚区域酪氨酸羟化酶样免疫反应性丧失。这些结果表明，并非所有纹状体D2多巴胺受体在多巴胺能去神经支配后都能增殖。
