al-Khalifa I J, Naidu N V, Nallari V R, Raut H I
Drug Control and Registration Centre, Ministry of Health, Safat, Kuwait.
J Pharm Pharmacol. 1989 Feb;41(2):127-8. doi: 10.1111/j.2042-7158.1989.tb06408.x.
A group of penicillins have been tested for their effect on the sensitivity of limulus amebocyte lysate test (LAL). Cloxacillin, cephalothin and cefuroxime inhibited the gel formation at concentrations above 2 mg mL-1, while ampicillin, methicillin and mecillinam showed no inhibitory effects upto concentrations of 10 mg mL-1. For benzylepenicillin the maximum non-inhibitory concentration was 10,000 units mL-1. However, the dilutions required to overcome inhibition were within the limits of maximum valid dilutions computed for each product showing that LAL test is valid for these products at their non-inhibitory concentrations.
已对一组青霉素对鲎试剂检测（LAL）灵敏度的影响进行了测试。氯唑西林、头孢噻吩和头孢呋辛在浓度高于2 mg/mL时会抑制凝胶形成，而氨苄西林、甲氧西林和美西林在浓度高达10 mg/mL时均未显示出抑制作用。对于苄青霉素，最大非抑制浓度为10,000单位/mL。然而，克服抑制所需的稀释度在每种产品计算出的最大有效稀释度范围内，这表明LAL检测在这些产品的非抑制浓度下对其有效。
