Attwood D, Ktistis G, McCormick Y, Story M J
Department of Pharmacy, University of Manchester, UK.
J Pharm Pharmacol. 1989 Feb;41(2):83-6. doi: 10.1111/j.2042-7158.1989.tb06398.x.
The effect of indomethacin on the micellar properties of the non-ionic surfactant, polysorbate 80, in water-sorbitol mixtures containing up to 25% w/v sorbitol has been investigated by light scattering, photon correlation spectroscopy and viscometric techniques. The molecular weight of polysorbate 80 micelles containing solubilized indomethacin increased linearly with increase of sorbitol concentration. Solubilization of indomethacin resulted in an increase of micellar weight due not only to the incorporation of solubilizate but also to an increase in the number of polysorbate molecules per micelle. The micelles in all systems were most satisfactorily represented as oblate ellipsoids, the asymmetry and hydration of which increased with increase of sorbitol concentration. Indomethacin solubilization caused a restructuring of the micelle to produce a more symmetrical micelle of increased hydration.
通过光散射、光子相关光谱法和粘度测量技术，研究了吲哚美辛对非离子表面活性剂聚山梨酯80在含高达25%（w/v）山梨醇的水 - 山梨醇混合物中的胶束性质的影响。含有增溶吲哚美辛的聚山梨酯80胶束的分子量随山梨醇浓度的增加而线性增加。吲哚美辛的增溶导致胶束重量增加，这不仅是由于增溶物的掺入，还由于每个胶束中聚山梨酯分子数量的增加。所有体系中的胶束最适合表示为扁椭球体，其不对称性和水合作用随山梨醇浓度的增加而增加。吲哚美辛的增溶导致胶束结构重组，产生水合作用增强的更对称胶束。
