Yang Hai-Yan, Yang Si-Yu, Shao Fu-Ye, Wang Hai-Yu, Wang Ya-Dong
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China E-mail :
Asian Pac J Cancer Prev. 2015;16(2):495-500. doi: 10.7314/apjcp.2015.16.2.495.
Published studies have reported relationships between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and lung cancer risk in Chinese population. However, the epidemiological results remained controversial. The objective of this study was to clarify the association of XRCC1 Arg399Gln polymorphism with lung cancer risk in the Chinese population.
Systematic searches were performed through the database of Medline/Pubmed, Web of Science, Embase, CNKI and WanFang Medical Online. Odds ratios (ORs) with 95% confidence interval (95%CI) were calculated to estimate the strength of the association.
Overall, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.36, 95%CI: 1.09-1.71) in the Chinese population on the basis of 19 studies with 5,416 cases and 5,782 controls. We did not observe any association between XRCC1 codon 399 Arg/Gln and Arg/Gln+Gln/Gln polymorphisms and lung cancer risk (OR=1.00, 95%CI: 0.92-1.08 and OR=1.05, 95%CI: 0.97- 1.13, respectively). Limiting the analysis to studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.18, 95%CI: 1.01-1.38). When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43).
Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population. Larger sample size studies are required to confirm our findings.
已发表的研究报告了中国人群中X射线修复交叉互补基因1（XRCC1）Arg399Gln多态性与肺癌风险之间的关系。然而，流行病学结果仍存在争议。本研究的目的是阐明XRCC1 Arg399Gln多态性与中国人群肺癌风险的关联。
通过Medline/Pubmed、科学网、Embase、中国知网和万方医学在线数据库进行系统检索。计算比值比（OR）及其95%置信区间（95%CI）以估计关联强度。
总体而言，基于19项研究（5416例病例和5782例对照），我们观察到中国人群中携带XRCC1密码子399 Gln/Gln基因型的受试者肺癌风险增加（OR = 1.36，95%CI：1.09 - 1.71）。我们未观察到XRCC1密码子399 Arg/Gln和Arg/Gln + Gln/Gln多态性与肺癌风险之间存在任何关联（OR分别为1.00，95%CI：0.92 - 1.08和OR = 1.05，95%CI：0.97 - 1.13）。将分析限于对照符合哈迪-温伯格平衡（HWE）的研究时，我们观察到携带XRCC1密码子399 Gln/Gln基因型的受试者肺癌风险增加（OR = 1.18，95%CI：1.01 - 1.38）。按对照来源分层时，我们观察到基于住院患者对照的情况下，携带XRCC1密码子399 Arg/Gln + Gln/Gln基因型的受试者肺癌风险增加（OR = 1.21，95%CI：(1.04 - 1.42)），以及基于健康受试者对照的情况下，携带XRCC1密码子399 Gln/Gln基因型的受试者肺癌风险增加（OR = 1.22，95%CI：1.04 - 1.43）。
我们的研究结果表明，某些XRCC1 Arg399Gln变异可能影响中国人群对肺癌的易感性。需要更大样本量的研究来证实我们的发现。
