Wang Ya-Dong, Zhai Wen-Long, Wang Hai-Yu, Xia Xiang-Qun
Henan Center for Disease Control and Prevention, Zhengzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(11):4443-8. doi: 10.7314/apjcp.2014.15.11.4443.
A number of studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism with susceptibility to hepatocellular carcinoma (HCC). However, the results were inconsistent and inconclusive. The aim of this study was to comprehensively explore the association of XRCC1 Arg399Gln variant with HCC risk.
Systematic searches of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database were performed. Pooled odds ratio (OR) with 95% confidence intervals (CI) was calculated to estimate the strength of association.
Overall, we observed an increased HCC risk among subjects carrying XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/ Gln+Arg/Gln genotypes (OR=1.20, 95%CI: 1.05-1.38, OR=1.16, 95%CI: 1.05-1.28, and OR=1.14, 95%CI: 1.04-1.24, respectively) based on 20 studies including 3374 cases and 4633 controls. In subgroup analysis, we observed an increased risk of XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/Gln+Arg/Gln polymorphisms for HCC in hospital-based study (OR=1.25, 95%CI: 1.03-1.51, OR=1.21, 95%CI: 1.07-1.36 and OR=1.18, 95%CI: 1.06-1.31, respectively) and in Asian population (OR=1.19, 95%CI: 1.03-1.38, OR=1.17, 95%CI: 1.04-1.30 and OR=1.14, 95%CI: 1.04-1.25, respectively). Limiting the analysis to the studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased HCC risk among Gln/Gln, Arg/Gln and Gln/ Gln+Arg/Gln genotype carriers (OR=1.17, 95%CI: 1.05-1.29, OR=1.12, 95%CI: 1.00-1.25 and OR=1.11, 95%CI: 1.02-1.21, respectively).
This updated meta-analysis results suggest that XRCC1 Arg399Gln variants may contribute to HCC risk. Well-designed studies with larger sample size were required to further verify our findings.
多项研究报告了X射线修复交叉互补基因1（XRCC1）的Arg399Gln多态性与肝细胞癌（HCC）易感性之间的关联。然而，结果并不一致且尚无定论。本研究的目的是全面探讨XRCC1 Arg399Gln变异与HCC风险之间的关联。
对PubMed、Elsevier、Science Direct、中国知网和中国生物医学文献数据库进行系统检索。计算合并比值比（OR）及其95%置信区间（CI）以估计关联强度。
总体而言，基于20项研究（包括3374例病例和4633例对照），我们观察到携带XRCC1密码子399 Gln/Gln、Arg/Gln和Gln/Gln+Arg/Gln基因型的受试者患HCC的风险增加（OR分别为1.20，95%CI：1.05 - 1.38；OR为1.16，95%CI：1.05 - 1.28；OR为1.14，95%CI：1.04 - 1.24）。在亚组分析中，我们观察到在基于医院的研究中（OR分别为1.25，95%CI：1.03 - 1.51；OR为1.21，95%CI：1.07 - 1.36；OR为1.18，95%CI：1.06 - 1.31）以及在亚洲人群中（OR分别为1.19，95%CI：1.03 - 1.38；OR为1.17，95%CI：1.04 - 1.30；OR为1.14，95%CI：1.04 - 1.25），XRCC1密码子399 Gln/Gln、Arg/Gln和Gln/Gln+Arg/Gln多态性导致HCC风险增加。将分析限制在对照符合哈迪 - 温伯格平衡（HWE）的研究中，我们观察到Gln/Gln、Arg/Gln和Gln/Gln+Arg/Gln基因型携带者患HCC的风险增加（OR分别为1.17，95%CI：1.05 - 1.29；OR为1.12，95%CI：1.00 - 1.25；OR为1.11，95%CI：1.02 - 1.21）。
这项更新的荟萃分析结果表明，XRCC1 Arg399Gln变异可能与HCC风险有关。需要设计更完善、样本量更大的研究来进一步验证我们的发现。
