哇巴因对树鼩、豚鼠和大鼠离体乳头肌的比较作用。
Comparative effects of ouabain on isolated papillary muscle from tree shrews, guinea-pigs and rats.
作者信息
Koga T, Shiraki Y, Sakai K
机构信息
Department of Pharmacology, Fujigotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan.
出版信息
J Pharm Pharmacol. 1989 Mar;41(3):212-3. doi: 10.1111/j.2042-7158.1989.tb06435.x.
Inotropic effects of ouabain were investigated in the isolated papillary muscle preparations of the tree shrew (Tupaia glis), guinea-pigs and rats. In the guinea-pig and shrew papillary muscles, ouabain at concentrations of 10(-8) to 3 x 10(-7) M caused a concentration-dependent positive inotropic response in a similar magnitude, while in the rat, ouabain at concentrations of 10(-7) to 3 x 10(-6) M elicited negative inotropic one. Either phentolamine or pindolol in a concentration sufficient to block the alpha- and beta-adrenoceptors did not antagonize the positive inotropic effect of ouabain in the papillary muscle preparation of the shrews.
在树鼩（笔尾树鼩）、豚鼠和大鼠的离体乳头肌标本中研究了哇巴因的变力作用。在豚鼠和树鼩的乳头肌中，浓度为10^(-8)至3×10^(-7)M的哇巴因引起类似幅度的浓度依赖性正性变力反应，而在大鼠中，浓度为10^(-7)至3×10^(-6)M的哇巴因引起负性变力反应。足以阻断α和β肾上腺素能受体的酚妥拉明或吲哚洛尔浓度均未拮抗树鼩乳头肌标本中哇巴因的正性变力作用。
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