Namiki Shunichi, Mitsuzuka Koji, Kaiho Yasuhiro, Yamada Shigeyuki, Adachi Hisanobu, Yamashita Shinichi, Saito Hideo, Ito Akihiro, Nakagawa Haruo, Takegami Misa, Arai Yoichi
Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Urology, Japan Community Health Care Organization Sendai Hospital, Sendai, Japan.
BJU Int. 2016 Mar;117(3):450-5. doi: 10.1111/bju.13083. Epub 2015 May 23.
To perform a longitudinal investigation of the correlation between functional recovery and sex hormone concentrations after radical prostatectomy (RP).
A total of 72 consecutive patients undergoing RP between January 2012 and June 2013 were prospectively included and serially followed after surgery for comparative analysis. Their luteinizing hormone (LH) and total testosterone (TT) concentrations were measured before surgery and 3 and 12 months after surgery. They also filled out a health-related quality of life questionnaire before and at 1, 3, 6 and 12 months after surgery.
The mean LH concentration increased from 4.28 U/L at baseline to 5.53 U/L at 3 months and remained high at 12 months after RP (both P < 0.001). There were no significant changes in the TT concentration after RP. LH at baseline was negatively correlated with the urinary function (UF) score at 3 and 12 months after RP (P = 0.030 and 0.032, respectively). After RP, subjects with high baseline LH (n = 37) were more likely than those with low LH concentrations to report lower UF scores (P = 0.014). Multivariate analysis of variance in an interaction of time × LH concentration for UF scores indicated a significant relationship between changes in UF score and LH concentration (P = 0.004).
Radical prostatectomy affects sex hormones by increasing LH concentrations, while TT concentrations remain stable after surgery. Baseline LH concentrations are significantly associated with the recovery of urinary outcomes after RP.
对根治性前列腺切除术后（RP）功能恢复与性激素浓度之间的相关性进行纵向研究。
前瞻性纳入了2012年1月至2013年6月期间连续接受RP的72例患者，并在术后进行连续随访以进行对比分析。在手术前以及术后3个月和12个月测量他们的促黄体生成素（LH）和总睾酮（TT）浓度。他们还在手术前以及术后1、3、6和12个月填写了一份与健康相关的生活质量问卷。
LH的平均浓度从基线时的4.28 U/L增加到3个月时的5.53 U/L，并在RP术后12个月时仍保持较高水平（均P < 0.001）。RP术后TT浓度无显著变化。基线时的LH与RP术后3个月和12个月时的尿功能（UF）评分呈负相关（分别为P = 0.030和0.032）。RP术后，基线LH水平高的受试者（n = 37）比LH浓度低的受试者更有可能报告较低的UF评分（P = 0.014）。对UF评分的时间×LH浓度交互作用进行多变量方差分析表明，UF评分变化与LH浓度之间存在显著关系（P = 0.004）。
根治性前列腺切除术通过增加LH浓度影响性激素，而术后TT浓度保持稳定。基线LH浓度与RP术后尿功能结局的恢复显著相关。
