Department of Orthopedic Surgery, Linyi People's Hospital, Linyi, 276000 China.
Department of Orthopedic Surgery, the First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001 China.
Cancer Cell Int. 2015 Feb 4;15(1):3. doi: 10.1186/s12935-014-0147-z. eCollection 2015.
Human malignant melanoma is a common primary malignant cutaneous tumour derived from transformed epidermal melanocytes. Patients with melanoma have a high rate of mortality due to resistance to chemotherapeutic drugs, a major obstacle to a successful treatment. Several reports have suggested that CD146 plays an important role as a signalling molecule in human melanoma. This role includes CD146 as a participant in inflammation, differentiation, adhesion, tumourigenicity, metastasis, invasion and angiogenesis among other processes, which suggests that this molecule promotes the progression of human melanoma as a multifaceted regulator. In this article, we explore the effects and corresponding mechanisms with respect to the role of CD146/MUC18 in the promotion of human melanoma progression. Collectively, the studies indicated that targeting CD146, because it is a suitable marker of poor patient outcome, might be useful in the design of future strategies for the prevention and treatment of human melanoma.
人类恶性黑色素瘤是一种常见的源自表皮黑色素细胞转化的原发性皮肤恶性肿瘤。由于对化疗药物的耐药性，黑色素瘤患者的死亡率很高，这是治疗成功的主要障碍。有几项报道表明，CD146 作为一种信号分子在人类黑色素瘤中发挥着重要作用。其作用包括 CD146 作为炎症、分化、黏附、致瘤性、转移、侵袭和血管生成等过程的参与者，这表明该分子作为一个多方面的调节剂促进了人类黑色素瘤的进展。在本文中，我们探讨了 CD146/MUC18 在促进人类黑色素瘤进展中的作用及其相应机制。总的来说，这些研究表明，针对 CD146 的治疗策略，因为它是患者预后不良的合适标志物，可能有助于设计未来预防和治疗人类黑色素瘤的策略。
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