培养的复合皮肤移植物：允许大量扩增的生物皮肤替代物。

Cultured composite skin grafts: biological skin equivalents permitting massive expansion.

作者信息

Nanchahal J, Otto W R, Dover R, Dhital S K

机构信息

Department of Anatomy, Charing Cross and Westminster Medical School, London, UK.

出版信息

Lancet. 1989 Jul 22;2(8656):191-3. doi: 10.1016/s0140-6736(89)90374-7.

DOI:10.1016/s0140-6736(89)90374-7

PMID:2568523

Abstract

After assessment in mice, a biological skin equivalent consisting of cultured fibroblasts in a collagen gel overlain with cultured keratinocytes was applied to three patients who had had tattoos excised. In all patients the grafts took well with good cosmetic results and little or no contracture. A biopsy at 4 weeks showed that the central graft area had a fully differentiated epidermis and a mature dermis without adnexae.

摘要

在对小鼠进行评估后，将一种生物皮肤替代物应用于3名切除纹身的患者，该替代物由胶原凝胶中培养的成纤维细胞和覆盖其上的培养角质形成细胞组成。在所有患者中，移植物生长良好，美容效果佳，挛缩轻微或无挛缩。4周时的活检显示，移植物中央区域有完全分化的表皮和无附属器的成熟真皮。