脑单胺氧化酶（MAO）B：一种独特的神经毒素和神经递质生成酶。

Brain monoamine oxidase (MAO) B: a unique neurotoxin and neurotransmitter producing enzyme.

作者信息

Youdim M B

机构信息

Rappaport Family Research Institute, Technion Faculty of Medicine, Department of Pharmacology, Haifa, Israel.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(3-4):363-71. doi: 10.1016/0278-5846(89)90125-5.

DOI:10.1016/0278-5846(89)90125-5

PMID:2568664

Abstract

The notion that monoamine oxidase (MAO) functions solely to inactivate neurotransmitter and other biogenic amines needs to be re-evaluated. It is now apparent that MAO-B is capable of oxidizing inert non-polar amines such as MPTP (N-methyl-4-phenyl-1,2,3,6, tetrahydropyridine) and milacemide (2-n-pentylaminoacetamide) into neuroactive substances giving rise to Parkinson inducing dopaminergic neurotoxin, MPP+ and inhibitory amino acid neurotransmitter, glycine respectively. These findings accord new prospectives for neuropsychotherapy with selective MAO-B inhibitors and substrates.

摘要

单胺氧化酶（MAO）仅起到使神经递质和其他生物胺失活作用的这一观念需要重新评估。现在很明显，MAO-B能够将诸如MPTP（N-甲基-4-苯基-1,2,3,6-四氢吡啶）和米拉酰胺（2-正戊基氨基乙酰胺）等惰性非极性胺氧化成神经活性物质，分别产生诱发帕金森病的多巴胺能神经毒素MPP⁺和抑制性氨基酸神经递质甘氨酸。这些发现为使用选择性MAO-B抑制剂和底物进行神经心理治疗带来了新的前景。