具有抗菌活性的聚甲基丙烯酸二乙氨基乙酯季铵盐。
Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity.
作者信息
Farah Shady, Aviv Oren, Laout Natalia, Ratner Stanislav, Beyth Nurit, Domb Abraham J
机构信息
Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience & Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience & Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
出版信息
Colloids Surf B Biointerfaces. 2015 Apr 1;128:608-613. doi: 10.1016/j.colsurfb.2015.01.051. Epub 2015 Feb 7.
Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer. QA-PDEAEM NPs of 50-70 nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C8 and N-C18 alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria.
季铵（QA）甲基丙烯酸酯单体和聚合物是由甲基丙烯酸N，N - 二乙氨基乙酯（DEAEM）单体的N - 烷基化反应合成的。基于QA - PDEAEM的线性共聚物以及首次报道的交联纳米颗粒（NPs），是通过季铵化的QA - DEAEM单体与甲基丙烯酸甲酯（MMA）或二乙烯基单体进行自由基聚合制备的。50 - 70纳米的QA - PDEAEM NPs被嵌入聚乙酸乙烯酯涂层中。制备了具有N - C8和N - C18烷基链的QA - 聚合物以及与甲基丙烯酸甲酯的共聚物，它们的摩尔比不同，并检测了其抗菌效果。这些涂层对四种代表性的革兰氏阳性菌和革兰氏阴性菌表现出很强的抗菌活性。
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