Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH, 44116, USA.
Ann Biomed Eng. 2023 Apr;51(4):833-845. doi: 10.1007/s10439-022-03100-1. Epub 2022 Oct 15.
Face masks have been proven to be medicine's best public health tool for preventing transmission of airborne pathogens. However, in situations with continuous exposure, lower quality and "do-it-yourself" face masks cannot provide adequate protection against pathogens, especially when mishandled. In addition, the use of multiple face masks each day places a strain on personal protective equipment (PPE) supply and is not environmentally sustainable. Therefore, there is a significant clinical and commercial need for a reusable, pathogen-inactivating face mask. Herein, we propose adding quaternary poly(dimethylaminohexadecyl methacrylate), q(PDMAHDM), abbreviated to q(PDM), to existing fabric networks to generate "contact-killing" face masks-effectively turning cotton, polypropylene, and polyester into pathogen resistant materials. It was found that q(PDM)-integrated face masks were able to inactivate both Gram-positive and Gram-negative bacteria in liquid culture and aerosolized droplets. Furthermore, q(PDM) was electrospun into homogeneous polymer fibers, which makes the polymer practical for low-cost, scaled-up production.
口罩已被证明是预防空气传播病原体传播的医学最佳公共卫生工具。然而，在持续暴露的情况下，质量较低的“自制”口罩无法为病原体提供足够的保护，尤其是在处理不当的情况下。此外，每天使用多个口罩会给个人防护设备 (PPE) 的供应带来压力，而且在环境上也不可持续。因此，临床上和商业上都非常需要一种可重复使用且能灭活病原体的口罩。在此，我们建议在现有的织物网络中添加季铵盐聚（二甲基氨基己基甲基丙烯酸酯），简称为 q(PDM)，以生成“接触式杀菌”口罩-将棉花、聚丙烯和聚酯有效地转化为抗病原体材料。研究发现，q(PDM)集成口罩能够在液体培养物和雾化液滴中灭活革兰氏阳性菌和革兰氏阴性菌。此外，q(PDM)被静电纺成均匀的聚合物纤维，这使得该聚合物非常适合低成本、规模化生产。
