Hayes T J, Roberts G K, Halliwell W H
Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
Toxicol Pathol. 1989;17(1 Pt 2):129-37. doi: 10.1177/019262338901700109.
The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, the expression of which can be precipitated in predisposed dogs by experimental treatment, and thus, its occurrence could complicate interpretation of toxicity studies. We have observed the disorder in 14 beagle dogs. The syndrome is rare and most cases for study were supplied by the breeder. Typical clinical signs observed included evidence of pain when the mouth was opened, grunting when lifted, and standing with an arched back and lowered head. Appetite was usually reduced. Body temperature was elevated (e.g., 104-106 degrees F). There was progressive, bilateral atrophy of temporal and cervical musculature. Such signs have been observed to persist unremittingly or, more commonly, with periods of expression and remission. Neutrophilic leukocytosis and thrombocytosis were present. Hemoglobin and hematocrit were usually slightly decreased. Serum total protein was usually normal but albumin was reduced and alpha-2 globulins were markedly increased. Rheumatoid factor was elevated in several dogs. Arteritis was observed histologically and was characterized by necrosis, intimal proliferation, neutrophil and mononuclear cell infiltration in the media and periarterial tissues, and hemorrhage. Amyloidosis was observed in several dogs. The cause of this disorder is unknown. Knowledge of the distinct features of this syndrome should obviate complication of interpretation of results in toxicity studies and hopefully will lead to studies of this syndrome to provide an understanding of its etiopathogenesis.
本文描述了一种犬类综合征的临床、实验室和病理特征，该综合征的特点为间歇性疼痛、发热、嗜中性粒细胞增多和坏死性动脉炎，旨在提醒参与毒性试验的其他人员注意这种疾病的存在。据认为，这种特发性综合征是一种潜伏性疾病，在易患犬中，通过实验性治疗可促使其症状显现，因此，其出现可能会使毒性研究结果的解释变得复杂。我们在14只比格犬中观察到了这种疾病。该综合征较为罕见，大多数用于研究的病例由饲养者提供。观察到的典型临床症状包括张嘴时疼痛的迹象、抱起时发出呼噜声、弓背低头站立。食欲通常减退。体温升高（例如，华氏104 - 106度）。颞部和颈部肌肉组织出现进行性双侧萎缩。这些症状被观察到持续存在，或者更常见的是，有发作期和缓解期。存在嗜中性白细胞增多和血小板增多。血红蛋白和血细胞比容通常略有降低。血清总蛋白通常正常，但白蛋白降低，α-2球蛋白明显升高。几只犬的类风湿因子升高。组织学观察到动脉炎，其特征为坏死、内膜增生、中性粒细胞和单核细胞浸润于中膜和动脉周围组织以及出血。几只犬中观察到淀粉样变性。这种疾病的病因尚不清楚。了解该综合征的独特特征应可避免毒性研究结果解释出现复杂情况，并有望促使对该综合征进行研究，以了解其病因发病机制。
