Berrens Rebecca V, Reik Wolf
Epigenetics Programme, The Babraham Institute, Cambridge, UK.
Epigenetics Programme, The Babraham Institute, Cambridge, UK The Wellcome Trust Sanger Institute, Cambridge, UK.
EMBO J. 2015 Mar 12;34(6):689-90. doi: 10.15252/embj.201591054. Epub 2015 Feb 16.
Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the role of the protein arginine methyltransferase 5 (PRMT5) as an important player in DNA protection during germline development in the mouse (Kim , & Li , 2015).
原始生殖细胞（PGCs）是形成精子和卵细胞的生殖细胞谱系的胚胎前体。为确保后代的生存，保护种系免受DNA损伤以及潜在的表观突变影响至关重要。最近的研究强调了蛋白质精氨酸甲基转移酶5（PRMT5）在小鼠生殖系发育过程中作为DNA保护重要参与者的作用（Kim和Li，2015年）。
Zotero 插件