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神经内分泌中线癌。

NUT midline carcinoma.

机构信息

Department of Pathology, Brigham and Women's Hospital, harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA.

出版信息

Nat Rev Cancer. 2014 Mar;14(3):149-50. doi: 10.1038/nrc3659.

DOI:10.1038/nrc3659
PMID:25688404
Abstract

NUT midline carcinoma, a squamous cell carcinoma, is one of the most aggressive human cancers, and there is a desperate need for effective therapies for patients with this disease. Will the new bromodomain and extra terminal (BET) inhibitors prove to be one such treatment for this rare and enigmatic cancer?

摘要

NUT 中线癌,一种鳞状细胞癌,是最具侵袭性的人类癌症之一,因此迫切需要为患有这种疾病的患者提供有效的治疗方法。新型溴结构域和末端外结构域(BET)抑制剂是否将成为治疗这种罕见而神秘癌症的一种方法?

相似文献

1
NUT midline carcinoma.神经内分泌中线癌。
Nat Rev Cancer. 2014 Mar;14(3):149-50. doi: 10.1038/nrc3659.
2
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Zhonghua Bing Li Xue Za Zhi. 2012 Aug;41(8):519-24. doi: 10.3760/cma.j.issn.0529-5807.2012.08.003.
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Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.靶向 p300/CBP HAT 结构域治疗 NUT 中线癌。
Oncogene. 2020 Jun;39(24):4770-4779. doi: 10.1038/s41388-020-1301-9. Epub 2020 May 4.
4
NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.NSD3-NUT 融合癌蛋白在中线 NUT 癌中的作用:对一种新的致癌机制的启示。
Cancer Discov. 2014 Aug;4(8):928-41. doi: 10.1158/2159-8290.CD-14-0014. Epub 2014 May 29.
5
NUT midline carcinoma: an aggressive intrathoracic neoplasm.NUT 中线癌:一种侵袭性的胸腔内肿瘤。
J Thorac Oncol. 2013 Oct;8(10):1335-8. doi: 10.1097/JTO.0b013e3182a00f41.
6
Pathogenesis of NUT midline carcinoma.NUT 中线癌的发病机制。
Annu Rev Pathol. 2012;7:247-65. doi: 10.1146/annurev-pathol-011811-132438. Epub 2011 Oct 17.
7
The first report of molecular characterized BRD4-NUT carcinoma in Brazil: a case report.巴西首例分子特征明确的BRD4-NUT癌病例报告
J Med Case Rep. 2019 Sep 7;13(1):279. doi: 10.1186/s13256-019-2213-6.
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NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.NUT癌:临床病理特征、发病机制及治疗
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A case of endobronchial NUT midline carcinoma with intraluminal growth.一例具有腔内生长特点的支气管内NUT中线癌。
Anticancer Res. 2015 Mar;35(3):1607-12.
10
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.BRD4-NUT 依赖性 NUT 中线癌的遗传修饰物揭示 BETi 和 CDK4/6i 之间的协同作用。
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Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma.抗血管生成疗法是对抗肺NUT中线癌斗争中的希望之光。
Front Med. 2025 Jun 14. doi: 10.1007/s11684-025-1145-3.
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Advancing Understanding and Therapeutic Strategies for NUT Sarcomas: Comprehensive Review of the Literature and Two Cases.NUT肉瘤的认识进展与治疗策略:文献综述及两例病例报告
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本文引用的文献

1
MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.BRD-NUT 下游靶标 MYC 对于 NUT 中线癌的分化阻断是必要且充分的。
Oncogene. 2014 Mar 27;33(13):1736-1742. doi: 10.1038/onc.2013.126. Epub 2013 Apr 22.
2
Clinicopathologic features and long-term outcomes of NUT midline carcinoma.NUT 中线癌的临床病理特征和长期预后。
Clin Cancer Res. 2012 Oct 15;18(20):5773-9. doi: 10.1158/1078-0432.CCR-12-1153. Epub 2012 Aug 15.
3
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
酷似恶性外周神经鞘瘤的融合性肉瘤伴长期生存
Biomedicines. 2024 Aug 1;12(8):1709. doi: 10.3390/biomedicines12081709.
4
Primary thyroid nuclear protein in testis carcinoma: a case report and literature review.睾丸癌中的原发性甲状腺核蛋白:一例报告及文献综述
Gland Surg. 2024 Jun 30;13(6):1116-1125. doi: 10.21037/gs-24-77. Epub 2024 Jun 24.
5
Maxillary Sinus NUT Carcinoma: A Case Report.上颌窦 NUT 癌:一例报告
Cancer Diagn Progn. 2024 May 3;4(3):370-378. doi: 10.21873/cdp.10334. eCollection 2024 May-Jun.
6
Top IHC/ISH Hacks for and Molecular Surrogates of Poorly Differentiated Sinonasal Small Round Cell Tumors.低分化鼻窦小圆细胞肿瘤的顶级免疫组化/原位杂交技巧及分子替代物
Head Neck Pathol. 2024 Feb 5;18(1):2. doi: 10.1007/s12105-023-01608-z.
7
Histopathological features of giant mediastinal tumors-a literature review.巨大纵隔肿瘤的组织病理学特征——文献综述
Mediastinum. 2023 Oct 20;7:37. doi: 10.21037/med-23-23. eCollection 2023.
8
Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice.除了肝癌,甲胎蛋白在临床实践中还有更多的应用场景。
Front Oncol. 2023 Sep 15;13:1231420. doi: 10.3389/fonc.2023.1231420. eCollection 2023.
9
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications.BET 溴结构域抑制剂:新颖的设计策略和治疗应用。
Molecules. 2023 Mar 29;28(7):3043. doi: 10.3390/molecules28073043.
10
Rare molecular subtypes of lung cancer.肺癌的罕见分子亚型。
Nat Rev Clin Oncol. 2023 Apr;20(4):229-249. doi: 10.1038/s41571-023-00733-6. Epub 2023 Feb 20.
通过表观基因组重编程来区分中央型 NUT 中线癌。
Cancer Res. 2011 Apr 1;71(7):2686-96. doi: 10.1158/0008-5472.CAN-10-3513. Epub 2011 Mar 29.
4
Selective inhibition of BET bromodomains.选择性抑制 BET 溴结构域。
Nature. 2010 Dec 23;468(7327):1067-73. doi: 10.1038/nature09504. Epub 2010 Sep 24.
5
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.通过将 CBP/p300 隔离在转录非活跃的高乙酰化染色质域中来致癌。
EMBO J. 2010 Sep 1;29(17):2943-52. doi: 10.1038/emboj.2010.176. Epub 2010 Jul 30.
6
Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.使用 NUT 特异性单克隆抗体诊断 NUT 中线癌。
Am J Surg Pathol. 2009 Jul;33(7):984-91. doi: 10.1097/PAS.0b013e318198d666.
7
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.BRD-NUT癌蛋白:一类密切相关的核蛋白,可阻断上皮分化并维持癌细胞生长。
Oncogene. 2008 Apr 3;27(15):2237-42. doi: 10.1038/sj.onc.1210852. Epub 2007 Oct 15.