Department of Pathology, Brigham and Women's Hospital, harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA.
Nat Rev Cancer. 2014 Mar;14(3):149-50. doi: 10.1038/nrc3659.
NUT midline carcinoma, a squamous cell carcinoma, is one of the most aggressive human cancers, and there is a desperate need for effective therapies for patients with this disease. Will the new bromodomain and extra terminal (BET) inhibitors prove to be one such treatment for this rare and enigmatic cancer?
NUT 中线癌,一种鳞状细胞癌,是最具侵袭性的人类癌症之一,因此迫切需要为患有这种疾病的患者提供有效的治疗方法。新型溴结构域和末端外结构域(BET)抑制剂是否将成为治疗这种罕见而神秘癌症的一种方法?