Stirt J A
Department of Anesthesiology, University of Virginia Medical Center, Charlottesville 22908.
Br J Anaesth. 1989 Jun;62(6):697-9. doi: 10.1093/bja/62.6.697.
Patients given combinations of non-depolarizing neuromuscular blocking drugs have been reported to recover from neuromuscular block more rapidly than patients given a single drug. This study was designed to assess if this phenomenon occurred with the combination of atracurium and vecuronium. During nitrous oxide-fentanyl anaesthesia, 30 adult patients were allocated randomly to receive atracurium 0.5 mg kg-1, vecuronium 0.1 mg kg-1, or a combination of atracurium 0.125 mg kg-1 + vecuronium 0.025 mg kg-1. All patients had 100% neuromuscular block, and times to block onset did not differ significantly between the three groups. Recovery to 10, 25, 50 and 90% of control twitch height was significantly faster in the group receiving the combination of drugs.
据报道，接受非去极化神经肌肉阻滞药物联合使用的患者，其神经肌肉阻滞恢复速度比接受单一药物的患者更快。本研究旨在评估阿曲库铵和维库溴铵联合使用时是否会出现这种现象。在氧化亚氮-芬太尼麻醉期间，30名成年患者被随机分配接受阿曲库铵0.5mg/kg、维库溴铵0.1mg/kg，或阿曲库铵0.125mg/kg + 维库溴铵0.025mg/kg的联合用药。所有患者均出现100%的神经肌肉阻滞，三组之间的阻滞起效时间无显著差异。接受联合用药的组恢复至对照抽搐高度的10%、25%、50%和90%的时间明显更快。
