Tajima Shogo, Suzuki Tomoyuki, Yamada Yukio, Morikawa Teppei, Minagawa Daisuke, Homma Yukio, Fukayama Masashi
Departments of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Med Mol Morphol. 2016 Sep;49(3):182-7. doi: 10.1007/s00795-015-0098-z. Epub 2015 Feb 18.
Invasive urothelial carcinoma with chordoid features has not been reported since being first documented in 2009. Here we report a further case of it, involving an 85-year-old man with a papillary tumor of the urinary bladder, measuring 3 cm in diameter. This case is unique in that an epithelial-mesenchymal transition was suspected to have occurred in the transformation of a conventional urothelial carcinoma to a sarcomatoid variant, with invasive urothelial carcinoma with chordoid features acting as an intermediate stage. Based on this finding, we recommend that the presence of invasive urothelial carcinoma with chordoid features should be reported as it may predict the coexistence or future development of an aggressive sarcomatoid variant.
具有索状特征的浸润性尿路上皮癌自2009年首次被记录以来尚未见报道。在此，我们报告另外一例，患者为一名85岁男性，患有直径3厘米的膀胱乳头状肿瘤。该病例的独特之处在于，在传统尿路上皮癌向肉瘤样变体转变过程中，怀疑发生了上皮-间质转化，具有索状特征的浸润性尿路上皮癌为中间阶段。基于这一发现，我们建议报告具有索状特征的浸润性尿路上皮癌的存在，因为它可能预示侵袭性肉瘤样变体的共存或未来发展。
