Kural Cahit, Simsek Gulcin Guler, Guresci Servet, Arslan Erhan, Kilic Cenk, Tehli Ozkan, Geyik Murat, Erbas Cem, Izci Yusuf
Department of Neurosurgery, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey.
Childs Nerv Syst. 2015 May;31(5):699-703. doi: 10.1007/s00381-015-2644-3. Epub 2015 Feb 18.
The aim of this study is to elucidate the architecture of these fine structures in human fetuses.
The histological examination of medial wall (MW) and lateral wall (LW) was performed in 15 normal human fetuses. Eleven fetuses were female and four were male. The gestational age ranged between 14 and 35 weeks. The weight ranged between 180 and 1750 g. The wall samples (two MW and two LW from each fetus) were obtained by microsurgical technique and underwent histological examination. Each wall was examined for the structure and composition of collagen and elastic fibers, ganglions, peripheral nerves, and vessels.
A total of 60 wall samples (30 MW and 30 LW) were examined in 15 fetuses. Loose connective tissue composed of type III collagen was observed in both of the walls. Elastic fibers were observed only in three wall samples (two MW and one LW). Ganglion was detected in 11 samples (nine in LW and two in MW), and peripheral nerve was found in 28 walls (18 LW and 10 MW). Vessels were observed in 51 samples (26 LW and 25 MW). None of the walls was stained with type I collagen.
The structure of LW and MW of the cavernous sinus (CS) in fetuses is mainly composed of collagen tissue while some elastic fibers are supported by this tissue. Type III collagen is the main component of fetal CS walls. Because of the weak histological structure, CS may be more prone to tumor invasion in infants.
本研究旨在阐明人类胎儿中这些精细结构的架构。
对15例正常人类胎儿的内侧壁（MW）和外侧壁（LW）进行组织学检查。11例胎儿为女性，4例为男性。孕周在14至35周之间。体重在180至1750克之间。通过显微外科技术获取壁样本（每个胎儿两个MW和两个LW）并进行组织学检查。检查每壁的胶原纤维和弹性纤维、神经节、周围神经及血管的结构和组成。
对15例胎儿共60个壁样本（30个MW和30个LW）进行了检查。在两壁中均观察到由III型胶原组成的疏松结缔组织。仅在3个壁样本（2个MW和1个LW）中观察到弹性纤维。在11个样本中检测到神经节（9个在LW，2个在MW），在28个壁（18个LW和10个MW）中发现周围神经。在51个样本（26个LW和25个MW）中观察到血管。无一壁被I型胶原染色。
胎儿海绵窦（CS）的LW和MW结构主要由胶原组织组成，同时该组织支撑一些弹性纤维。III型胶原是胎儿CS壁的主要成分。由于组织学结构薄弱，CS在婴儿期可能更容易受到肿瘤侵袭。
