Bassal Ravit, Schejter Eduardo, Bachar Rachel, Shapira Hagit, Kaufman Zalman, Cohen Dani, Keinan-Boker Lital
Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, School of Public Health, Tel Aviv University, Tel-Aviv, Israel,
Arch Gynecol Obstet. 2015 Aug;292(2):405-13. doi: 10.1007/s00404-015-3655-8. Epub 2015 Feb 19.
This study describes time trends of cervical cancer and Cervical Intraepithelial Neoplasia 3 (CIN3) in Israel in the years 1986-2010 and characterizes these patients by demographics.
A retrospective survey based on cervical cancer and CIN3 data documented in the computerized system of the second largest Health Maintenance Organizations (HMO) in Israel, "Maccabi Healthcare Services" (MHS) between 1986 and 2010.
737 cervical cancer patients and 3,459 patients of CIN3 were reported between 1986 and 2010. The mean age of women with cervical cancer was significantly higher (mean 49.1 years) than that of CIN3 patients (mean 36.3 years) (p-value < 0.0001). The annual age-adjusted incidence rate of cervical cancer increased significantly from 1.6 per 100,000 in 1986 to 3.7 per 100,000 in 2010 (p for trend = 0.0001) and for CIN3, from 3.9 per 100,000 in 1986 to 40.4 per 100,000 in 2010 (p for trend = 0.0001). For cervical cancer, using the Joinpoint software we demonstrated an increase in the age-adjusted incidence rate between 1986 and 2003 and since then, a decrease was observed. Cervical cancer and CIN3 were mostly common in the Tel Aviv District.
Although quite low to begin with, the incidence rates of cervical cancer and CIN3 in Israel may be further lowered by implementing an organized screening program and introduction of the HPV vaccine into the national immunization program.
本研究描述了1986 - 2010年以色列宫颈癌和宫颈上皮内瘤变3级（CIN3）的时间趋势，并按人口统计学特征对这些患者进行了描述。
基于以色列第二大健康维护组织（HMO）“马卡比医疗服务”（MHS）1986年至2010年计算机系统中记录的宫颈癌和CIN3数据进行回顾性调查。
1986年至2010年期间报告了737例宫颈癌患者和3459例CIN3患者。宫颈癌女性患者的平均年龄（平均49.1岁）显著高于CIN3患者（平均36.3岁）（p值<0.0001）。宫颈癌的年龄调整发病率从1986年的每10万人1.6例显著增加到2010年的每10万人3.7例（趋势p值 = 0.0001），CIN3则从1986年的每10万人3.9例增加到2010年的每10万人40.4例（趋势p值 = 0.0001）。对于宫颈癌，使用Joinpoint软件我们证明1986年至2003年期间年龄调整发病率有所增加，此后观察到下降。宫颈癌和CIN3在特拉维夫地区最为常见。
尽管以色列宫颈癌和CIN³的发病率最初相当低，但通过实施有组织的筛查计划并将人乳头瘤病毒（HPV）疫苗纳入国家免疫计划，发病率可能会进一步降低。
