Li Feng, Zhang Jingwen, Arfuso Frank, Chinnathambi Arunachalam, Zayed M E, Alharbi Sulaiman Ali, Kumar Alan Prem, Ahn Kwang Seok, Sethi Gautam
Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute, National University of Singapore, Singapore, 117597, Singapore.
Arch Toxicol. 2015 May;89(5):711-31. doi: 10.1007/s00204-015-1470-4. Epub 2015 Feb 18.
The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.
在过去几十年中，转录因子核因子κB（NF-κB）在癌症研究领域引起了越来越多的关注。在多种实体瘤和血液系统恶性肿瘤中经常会出现这种转录因子的异常激活。NF-κB家族成员及其调控的基因与恶性转化、肿瘤细胞增殖、存活、血管生成、侵袭/转移以及治疗抗性有关。在本综述中，我们重点介绍了NF-κB信号通路在不同类型人类癌症中被组成性激活的多种分子机制，以及该转录因子调控的各种致癌基因在癌症发生和发展中的潜在作用。此外，还简要讨论了针对失调的NF-κB信号通路所采用的各种药理学方法及其在癌症治疗中的可能治疗潜力。
