飞行时间PET/MRI与PET/CT系统的临床与实验比较

A Clinical and Experimental Comparison of Time of Flight PET/MRI and PET/CT Systems.

作者信息

Oprea-Lager Daniela E, Yaqub Maqsood, Pieters Indra C, Reinhard Rinze, van Moorselaar Reindert J A, van den Eertwegh Alfons J M, Hoekstra Otto S, Lammertsma Adriaan A, Boellaard Ronald

机构信息

Department of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007, MB, Amsterdam, The Netherlands.

Department of Urology, VU University Medical Center, PO Box 7057, 1007, MB, Amsterdam, The Netherlands.

出版信息

Mol Imaging Biol. 2015 Oct;17(5):714-25. doi: 10.1007/s11307-015-0826-8.

PURPOSE

The purpose of the study was to compare image quality and quantitative accuracy of positron emission tomography/magnetic resonance imaging (PET/MRI) and PET/computed tomography (PET/CT) systems with time of flight PET gantries, using phantom and clinical studies.

PROCEDURES

Identical phantom experiments were performed on both systems. Calibration, uniformity, and standardized uptake value (SUV) recovery were measured. A clinical PET/CT versus PET/MRI comparison was performed using [(18)F]fluoromethylcholine ([(18)F]FCH).

RESULTS

Calibration accuracy and image uniformity were comparable between systems. SUV recovery met EANM/EARL requirements on both scanners. Thirty-four lesions with comparable PET image quality were identified. Lesional SUVmax differences of 4 ± 26% between PET/MRI and PET/CT data were observed (R (2) = 0.79, slope = 1.02). In healthy tissues, PET/MRI-derived SUVs were 16 ± 11% lower than on PET/CT (R (2) = 0.98, slope = 0.86).

CONCLUSION

PET/MRI and PET/CT showed comparable performance with respect to calibration accuracy, image uniformity, and SUV recovery. [(18)F]FCH uptake values for both healthy tissues and lesions corresponded reasonably well between MR- and CT-based systems, but only in regions free of MR-based attenuation artifacts.

目的

本研究旨在通过体模和临床研究，比较具有飞行时间功能的正电子发射断层扫描/磁共振成像（PET/MRI）系统和PET/计算机断层扫描（PET/CT）系统的图像质量和定量准确性。

程序

在两个系统上进行相同的体模实验。测量校准、均匀性和标准化摄取值（SUV）恢复情况。使用[（18）F]氟甲基胆碱（[（18）F]FCH）进行临床PET/CT与PET/MRI的比较。

结果

系统间校准准确性和图像均匀性相当。两个扫描仪的SUV恢复均符合欧洲核医学与分子影像学会/欧洲放射学会指南（EANM/EARL）要求。识别出34个PET图像质量相当的病变。观察到PET/MRI和PET/CT数据之间病变SUVmax差异为4±26%（R（2）=0.79，斜率=1.02）。在健康组织中，PET/MRI得出的SUV比PET/CT低16±11%（R（2）=0.98，斜率=0.86）。