Bansilal Sameer, Vedanthan Rajesh, Woodward Mark, Iyengar Rupa, Hunn Marilyn, Lewis Marcelle, Francis Lesley, Charney Alexander, Graves Claire, Farkouh Michael E, Fuster Valentin
Mount Sinai School of Medicine, New York, NY, USA.
George Institute, University of Sydney, Sydney, Australia.
Glob Heart. 2012 Jul;7(2):87-94. doi: 10.1016/j.gheart.2012.06.002.
The Grenada Heart Project aims to study the clinical, biological, and psychosocial determinants of the cardiovascular health in Grenada in order to develop and implement a nationwide cardiovascular health promotion program.
We recruited 2,827 adults randomly selected from the national electronic voter list. The main outcome measures were self-reported cardiovascular disease and behavioral risk factors, anthropometric measures, blood pressure, point-of-care testing for glucose and lipids, and ankle-brachial index. Risk factors were also compared with the U.S. National Health and Nutritional Survey data.
Prevalence of cardiovascular disease risk factors were: overweight and obesity-57.7% of the population, physical inactivity-23.4%, diabetes-13.3%, hypertension-29.7%, hypercholesterolemia-8.6%, and smoking-7%. Subjects who were physically active had a significantly lower 10-year Framingham risk score (p<0.001). Compared with the U.S. National Health and Nutrition Survey data, Grenadian women had higher rates of adiposity, diabetes, hypertension, and elevated low-density lipoprotein cholesterol, whereas Grenadian men had a higher rate of diabetes, a similar rate of hypertension, and lower rates of the other risk factors. Prevalence of peripheral arterial disease was 7.6%; stroke and coronary heart disease were equally prevalent at ∼2%.
This randomly selected adult sample in Grenada reveals prevalence rates of obesity, hypertension, and diabetes significantly exceeding those seen in the United States. The contrasting, paradoxically low levels of prevalent cardiovascular disease support the concept that Grenada is experiencing an obesity-related "risk transition." These data form the basis for the implementation of a pilot intervention program based on the Institute of Medicine recommendations and may serve as a model for other low- and middle-income countries.
格林纳达心脏项目旨在研究格林纳达心血管健康的临床、生物学和社会心理决定因素,以便制定并实施一项全国性心血管健康促进计划。
我们从国家电子选民名单中随机招募了2827名成年人。主要结局指标包括自我报告的心血管疾病和行为危险因素、人体测量指标、血压、血糖和血脂即时检测以及踝臂指数。还将危险因素与美国国家健康和营养调查数据进行了比较。
心血管疾病危险因素的患病率分别为:超重和肥胖——占人口的57.7%,身体活动不足——23.4%,糖尿病——13.3%,高血压——29.7%,高胆固醇血症——8.6%,吸烟——7%。身体活跃的受试者10年弗明汉风险评分显著更低(p<0.001)。与美国国家健康和营养调查数据相比,格林纳达女性肥胖、糖尿病、高血压和低密度脂蛋白胆固醇升高的发生率更高,而格林纳达男性糖尿病发生率更高,高血压发生率相似,其他危险因素发生率更低。外周动脉疾病的患病率为7.6%;中风和冠心病的患病率相当,约为2%。
在格林纳达随机抽取的这个成人样本显示,肥胖、高血压和糖尿病的患病率显著超过美国。与之形成对比且矛盾的是,心血管疾病的普遍患病率较低,这支持了格林纳达正在经历与肥胖相关的“风险转变”这一概念。这些数据构成了基于医学研究所建议实施试点干预项目的基础,并可能成为其他低收入和中等收入国家的一个范例。