癌症基因组图谱（TCGA）：一个不可估量的知识来源。
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge.
作者信息
Tomczak Katarzyna, Czerwińska Patrycja, Wiznerowicz Maciej
机构信息
Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, The Greater Poland Cancer Centre, Poznan, Poland.
Laboratory of Gene Therapy, Department of Cancer Immunology, The Greater Poland Cancer Centre, Poznan, Poland ; Department of Cancer Immunology and Diagnostics, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.
出版信息
Contemp Oncol (Pozn). 2015;19(1A):A68-77. doi: 10.5114/wo.2014.47136.
The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and discover major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. So far, TCGA researchers have analysed large cohorts of over 30 human tumours through large-scale genome sequencing and integrated multi-dimensional analyses. Studies of individual cancer types, as well as comprehensive pan-cancer analyses have extended current knowledge of tumorigenesis. A major goal of the project was to provide publicly available datasets to help improve diagnostic methods, treatment standards, and finally to prevent cancer. This review discusses the current status of TCGA Research Network structure, purpose, and achievements.
癌症基因组图谱（TCGA）是一个由公共资金资助的项目，旨在对主要的致癌基因组改变进行编目和发现，以创建一个全面的癌症基因组图谱“地图集”。到目前为止，TCGA的研究人员已经通过大规模基因组测序和综合多维度分析，对30多种人类肿瘤的大型队列进行了分析。对个别癌症类型的研究以及全面的泛癌分析扩展了目前对肿瘤发生的认识。该项目的一个主要目标是提供公开可用的数据集，以帮助改进诊断方法、治疗标准，并最终预防癌症。本综述讨论了TCGA研究网络的结构、目的和成就的现状。
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