MRPL18促进乳腺癌进展：将线粒体核糖体蛋白与免疫反应联系起来。
MRPL18 Promotes Breast Cancer Progression: Connecting Mitochondrial Ribosomal Protein to Immune Response.
作者信息
Li Hailong, Ouyang Wen, Long Yiyin, Peng Yun, Liu Ziyi, Zhou Qi, Xu Rong, Du Wei
机构信息
Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, 415000, China.
Medical Department, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, 415000, China.
出版信息
Oncol Res. 2025 Aug 28;33(9):2549-2571. doi: 10.32604/or.2025.065050. eCollection 2025.
BACKGROUND
The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer.
METHODS
Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models. Protein-protein interaction (PPI) networks were constructed by using GeneMANIA. Enrichment analysis is used to explore the signaling pathway regulated by MRPL18. Cell counting kit-8 (CCK-8) assays, colony formation, migration assays, flow cytometry, and xenograft models were employed to evaluate the role of MRPL18 in tumor progression. The immune response of MRPL18 was examined using correlation analysis.
RESULTS
High levels of MRPL18 are considered a risk factor in breast cancer. and studies demonstrated that MRPL18 promotes proliferation and migration in breast cancer. Besides, results found that MRPL18 promotes tumor growth through the activation of phosphatidylinositol 3-kinase (PI3K). Furthermore, high MRPL18 expression was linked to reduced immunotherapy efficacy, as indicated by correlations with immune checkpoints and immune-infiltrating patterns.
CONCLUSION
MRPL18 promotes the progression of breast cancer.
背景
本研究旨在探讨线粒体核糖体蛋白L18（MRPL18）在乳腺癌中的临床价值。
方法
使用多个数据库验证MRPL18的表达。通过预测模型评估MRPL18的预后影响和预测价值。使用GeneMANIA构建蛋白质-蛋白质相互作用（PPI）网络。采用富集分析来探索由MRPL18调控的信号通路。使用细胞计数试剂盒-8（CCK-8）检测、集落形成、迁移检测、流式细胞术和异种移植模型来评估MRPL18在肿瘤进展中的作用。使用相关性分析检测MRPL18的免疫反应。
结果
高水平的MRPL18被认为是乳腺癌的一个危险因素。 和 研究表明，MRPL18促进乳腺癌的增殖和迁移。此外，结果发现MRPL18通过激活磷脂酰肌醇3激酶（PI3K）促进肿瘤生长。此外，如与免疫检查点和免疫浸润模式的相关性所示，MRPL18高表达与免疫治疗疗效降低有关。
结论
MRPL18促进乳腺癌的进展。
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