Ding Feiqing, William Ronny, Kock Si Min, Leow Min Li, Liu Xue-Wei
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Chem Commun (Camb). 2015 Mar 18;51(22):4639-42. doi: 10.1039/c4cc09904d.
An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal as the key step.
本文公开了一种高效高产的海葵毒素B合成方法。通过引入我们的新策略，即通过烯丙醇的区域和立体选择性串联氢胺化/糖基化反应直接获得3-氨基-2,3-二脱氧糖，设计了一种简洁的8步氮杂环丁烷醛合成方法，该步骤为关键步骤。
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