通过糖醛的区域和立体选择性串联氢胺化-糖苷化反应，可方便获得 3-氨基-2,3-二脱氧糖。
Ready access to 3-amino-2,3-dideoxysugars via regio- and stereo-selective tandem hydroamination-glycosylation of glycals.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore.
出版信息
Org Biomol Chem. 2011 May 21;9(10):3929-39. doi: 10.1039/c1ob05068k. Epub 2011 Mar 30.
PMID:21451824
Abstract
A highly stereoselective BF(3)·OEt(2)-promoted tandem hydroamination-glycosylation on a glycal scaffold has been developed to form 3-amino-2,3-dideoxysugars in a one-pot procedure. This efficient multicomponent reaction protocol offers simplicity and general applicability to a broad range of variations on each component.
摘要
已开发出一种在糖醛骨架上通过高度对映选择性的 BF(3)·OEt(2)促进的串联氢胺化-糖苷化反应，以一锅法形成 3-氨基-2,3-二脱氧糖。这种高效的多组分反应方案具有简单性和通用性，适用于每个组分的广泛变化。
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