Cuttat J F, Ruchat P, Chapuis G
Service de chirurgie A, Centre hospitalier universitaire vaudois, Lausanne.
Schweiz Med Wochenschr. 1989 May 27;119(21):729-30.
Between 1976, date of the introduction of anti-H2, and 1987, 716 patients were hospitalized and operated on for ulcer disease in the surgical department of this hospital. The present study shows that 1. the annual number of operations has regressed by some 30%, 2. while the number of gastric ulcers remains constant on the whole, cases of acute duodenal ulcer have diminished by half, 3. cases of chronic, recurrent, or therapy-resistent duodenal ulcer have increased some tenfold (2 out of 78 in 1976 and 14 out of 45 in 1987), 4. the same is true of perforated ulcers (12 out of 78 in 1976 and 10 out of 45 in 1987) and hemorrhages (12 out of 78 and 10 out of 45), 5. surgery for stenosis has remained constant. -Proximal selective vagotomy has been the treatment of choice since 1981 in over 80% of duodenal ulcers. Operative mortality affects only elderly patients undergoing emergency surgery for complicated ulcer (two thirds perforations, one third hemorrhages). It is 2.6%. We thus confirm the reduced role of surgery in the treatment of gastric ulcer, while redefining the present surgical indications.
从1976年(抗H2药物引入之年)至1987年,本院外科有716例患者因溃疡病住院并接受手术治疗。本研究表明:1. 每年的手术例数减少了约30%;2. 胃溃疡病例总体保持稳定,而急性十二指肠溃疡病例减少了一半;3. 慢性、复发性或难治性十二指肠溃疡病例增加了约10倍(1976年78例中有2例,1987年45例中有14例);4. 穿孔性溃疡(1976年78例中有12例,1987年45例中有10例)和出血性溃疡(1976年78例中有12例,1987年45例中有10例)情况也是如此;5. 狭窄手术例数保持稳定。自1981年以来,超过80%的十二指肠溃疡患者首选近端选择性迷走神经切断术。手术死亡率仅影响因溃疡并发症接受急诊手术的老年患者(三分之二为穿孔,三分之一为出血)。死亡率为2.6%。因此,我们证实了手术在胃溃疡治疗中作用的降低,同时重新明确了目前的手术指征。