Cuocolo A, McCarthy K E, Sandrock D, Miller D L, Neumann R D
Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20892.
Urol Radiol. 1989;11(2):69-76. doi: 10.1007/BF02926480.
Renovascular hypertension is a major complication of Takayasu's arteritis, which contributes to the high mortality associated with the disease. We studied 5 patients affected by different degrees of Takayasu's arteritis to assess the usefulness of radionuclide renography in evaluating renal perfusion and function, and to predict changes induced by the disease before and after therapeutic interventions. Computer-assisted dynamic renal imaging with Tc-99m diethylenetriaminepentaacetic acid (DPTA) and I-131 orthoiodohippurate (OIH), and renal arteriography were concurrently performed in all patients. Two patients with hemodynamically insignificant renal artery stenosis showed normal perfusion and function by renography. Three patients had significant renal artery stenosis and functional changes on renography. Subsequently, two of these patients had successful therapy (one had bilateral renal artery bypass grafts, and the other had renal artery angioplasty), and both showed functional improvement at renography. Our results demonstrate that radionuclide renography is valuable in the assessment of functional changes induced by Takayasu's arteritis as well as for determining the response to therapeutic interventions.
肾血管性高血压是高安动脉炎的主要并发症，这导致了与该疾病相关的高死亡率。我们研究了5例患有不同程度高安动脉炎的患者，以评估放射性核素肾图在评估肾脏灌注和功能方面的实用性，并预测疾病在治疗干预前后引起的变化。所有患者均同时进行了锝-99m二乙三胺五乙酸（DPTA）和碘-131邻碘马尿酸（OIH）的计算机辅助动态肾脏成像以及肾动脉造影。两名肾动脉狭窄对血流动力学影响不显著的患者，肾图显示灌注和功能正常。三名患者存在显著的肾动脉狭窄且肾图有功能改变。随后，其中两名患者治疗成功（一名接受了双侧肾动脉搭桥术，另一名接受了肾动脉血管成形术），两人肾图均显示功能改善。我们的结果表明，放射性核素肾图在评估高安动脉炎引起的功能变化以及确定对治疗干预的反应方面具有重要价值。
