Marette P, Molle B, Mas J L, Kahan A, Devaux J Y, Toussaint M, Volkringer P, Fouchard J
Service des Maladies Cardiovasculaires, Hôpital Cochin, Paris.
Ann Cardiol Angeiol (Paris). 1989 Jun;38(6):305-8.
A patient affected with periarteritis nodosa and angina, presented a normal coronary angiography of the coronary trunks and an alteration of the left ventricular systolic function, improved by nicardipine, as well as a pre-capillary pulmonary hypertension with isolated, right cardiac repercussions, without pulmonary fibrosis nor thromboembolic disease. In addition, he presented three transient cerebral ischaemic accidents, with different localizations, which could not be related to a right aneurysm of the sylvian artery. Isolated precapillary pulmonary hypertension, without pulmonary fibrosis, which is not described in the course of periarteritis nodosa, seems related to an arteriolar involvement which is the known substratum of other visceral involvement in periarteritis nodosa. Improvement of the left ventricular function with nicardipine, administered acutely, suggest a partially reversible disorder of the coronary microcirculation.
一名患有结节性多动脉炎和心绞痛的患者，其冠状动脉主干的冠状动脉造影正常，但左心室收缩功能出现改变，尼卡地平可使其改善，同时存在单纯的毛细血管前性肺动脉高压及右心受累，无肺纤维化及血栓栓塞性疾病。此外，他出现了三次不同部位的短暂性脑缺血发作，这与大脑中动脉右动脉瘤无关。单纯的毛细血管前性肺动脉高压且无肺纤维化，在结节性多动脉炎病程中未见描述，似乎与小动脉受累有关，而小动脉受累是结节性多动脉炎其他内脏受累的已知基础。急性给予尼卡地平后左心室功能改善，提示冠状动脉微循环存在部分可逆性紊乱。
