Meng Xing, Pei Hui, Lan Chao
a Department of Emergency , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , P.R. China.
Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Sep;27(5):3311-2. doi: 10.3109/19401736.2015.1018199. Epub 2015 Feb 19.
We reported here the possible role of a mitochondrial tRNA mutation: T4353C in clinical expression of essential hypertension in Chinese population. The human mammalian mitochondrial tRNA database was used to analyze the conservation index of this mutation between different species. Moreover, phylogenetic analysis showed that the T4353C mutation belonged to human mitochondrial haplogroup HV, a West Eurasian haplogroup found throughout Western Asia and Eastern European but was infrequent in China. In addition, structural prediction of the T4353C mutation indicated that this transition did not alter the secondary structure of tRNA(Gln). Together, our data indicated that the T4353C mutation occurred infrequent and may not be associated with essential hypertension in Han Chinese population.
