Lin Yan, Lin Lian-Jie, Jin Yu, Cao Yong, Zhang Ying, Zheng Chang-Qing, Liu Jia-Li, Yang Sheng-Li
Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200000, China.
Biomed Res Int. 2015;2015:430185. doi: 10.1155/2015/430185. Epub 2015 Jan 28.
Aberrant expression of high mobility group box-1 protein (HMGB1) contributes to the progression of various inflammatory diseases. This meta-analysis focused on the clinical significance of serum HMGB1 levels in pancreatitis patients, with the goal of building a novel diagnostic score model.
We conducted a meta-analysis by searching in the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases without any language restrictions. Studies were pooled and standard mean difference (SMD) and its corresponding 95% confidence intervals (95% CIs) were calculated. Version 12.0 STATA software was used for statistical analysis.
We performed a final analysis of 841 subjects from 12 clinical case-control studies. The meta-analysis results showed a positive association between serum HMGB1 levels and the progression of pancreatitis. In the subgroup analysis by country, high serum level of HMGB1 may be related to pancreatitis progression in China, Korea, Hungary, and Japan populations (all P < 0.05).
The present meta-analysis indicated that serum HMGB1 level was statistically elevated in patients with pancreatitis, and thus serum levels of HMGB1 could be determined to be a useful biomarker for pancreatitis patients.
高迁移率族蛋白B1（HMGB1）的异常表达促进了各种炎症性疾病的进展。本荟萃分析聚焦于胰腺炎患者血清HMGB1水平的临床意义，旨在构建一种新型诊断评分模型。
我们通过检索PubMed、Embase、Web of Science、Cochrane图书馆、CISCOM、CINAHL、谷歌学术、中国生物医学文献数据库（CBM）和中国知网（CNKI）数据库进行荟萃分析，无任何语言限制。汇总研究并计算标准化均数差（SMD）及其相应的95%置信区间（95%CI）。使用STATA 12.0软件进行统计分析。
我们对来自12项临床病例对照研究的841名受试者进行了最终分析。荟萃分析结果显示血清HMGB1水平与胰腺炎进展之间存在正相关。在按国家进行的亚组分析中，血清HMGB1水平升高可能与中国、韩国、匈牙利和日本人群的胰腺炎进展有关（所有P<0.05）。
本荟萃分析表明，胰腺炎患者血清HMGB1水平在统计学上升高，因此血清HMGB1水平可被确定为胰腺炎患者的有用生物标志物。
