RHCE变异等位基因：RHCE*ce254G,733G。

RHCE variant allele: RHCE*ce254G,733G.

作者信息

Keller Jessica A, Horn Trina, Chiappa Colleen, Melland Camilla, Vietz Christine, Castilho Lilian, Keller Margaret A

机构信息

MS, Lead Molecular Technologist.

MS, Supervisor, American Red Cross, National Molecular Laboratory.

出版信息

Immunohematology. 2014;30(3):121-2.

PMID:25695437

Abstract

A novel RHCE allele was identified in a 53-year-old African American female blood donor with an Rh phenotype of D+ C– E– c+ e+ and a negative antibody screen. The donor’s cells typed e+ with all antisera tested. By gel-based genotyping and cDNA analysis, the two RHCE alleles in this donor were characterized. One allele was found to be the known allele RHCE01.20.01 (RHCEce733G) and the second was novel: RHCE01.06.02 (RHCEce254G,733G).

摘要

在一名53岁的非裔美国女性献血者中鉴定出一种新的RHCE等位基因，该献血者的Rh表型为D + C– E– c+ e+，抗体筛查呈阴性。供者的细胞与所有检测的抗血清反应均为e+型。通过基于凝胶的基因分型和cDNA分析，对该供者的两个RHCE等位基因进行了鉴定。发现一个等位基因为已知的等位基因RHCE01.20.01（RHCEce733G），另一个是新的：RHCE01.06.02（RHCEce254G,733G）。