White N W
Department of Medicine, Groote Schuur Hospital, University of Cape Town, South Africa.
Lancet. 1989 Aug 19;2(8660):434-5. doi: 10.1016/s0140-6736(89)90603-x.
In a retrospective analysis of clinically diagnosed and lower limb deep vein thrombosis (DVT) proven by contrast venography, DVT complicated admissions in 46 (3.4%) of 1366 adult patients treated in a tuberculosis hospital during 1986. Analysis of 7542 admissions during 1978-86 showed a relative risk of 4.74 in patients treated with regimens including rifampicin compared with other regimens. DVT was significantly more common in winter months and usually occurred within 2 weeks of treatment being started. This probable association between rifampicin and DVT does not contraindicate use of this drug, but measures to prevent DVT should be taken in inpatients receiving rifampicin.
在一项对经临床诊断并经静脉造影证实的下肢深静脉血栓形成（DVT）的回顾性分析中，1986年期间在一家结核病医院接受治疗的1366例成年患者中有46例（3.4%）因DVT而并发入院。对1978 - 1986年期间7542例入院病例的分析显示，与其他治疗方案相比，接受含利福平治疗方案的患者发生DVT的相对风险为4.74。DVT在冬季月份明显更为常见，且通常在开始治疗后的2周内发生。利福平与DVT之间的这种可能关联并不构成使用该药的禁忌，但对接受利福平治疗的住院患者应采取预防DVT的措施。
