Zhang X, Silva E, Gershenson D, Hung M C
University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Oncogene. 1989 Aug;4(8):985-9.
There are two genes related to the v-erb B oncogene in the human genome. The c-erb B-1 gene encodes the epidermal growth factor receptor (EGF-r), and the c-erb B-2/neu gene encodes a receptor-like protein very similar to, but distinct from the EGF-r. Southern blot analysis of DNAs from 15 fresh human ovarian carcinomas showed that the c-erb B-2/neu gene was amplified in 3 tumors. The c-erb B-1/EGF-r gene was not amplified. However, in one case of adenocarcinoma of uterine endometrium, the c-erb B-1/EGF-r was found to be rearranged in the 5' region of this gene. The genomic structure of the rearranged c-erb B-1/EGF-r gene is similar to those found in the chicken v-erb B oncogene, which produces a truncated form of the EGF-r. The results suggest that amplification of the c-erb B-2/neu gene may play a role in the pathogenesis of ovarian carcinoma. Further, the human c-erb B-1/EGF-r gene in adenocarcinoma of uterine endometrium may be activated by a similar mechanism as that in the chicken v-erb B oncogene.
人类基因组中有两个与v-erb B癌基因相关的基因。c-erb B-1基因编码表皮生长因子受体（EGF-r），而c-erb B-2/neu基因编码一种与EGF-r非常相似但又不同的受体样蛋白。对15例新鲜人卵巢癌DNA进行的Southern印迹分析表明，3例肿瘤中c-erb B-2/neu基因发生了扩增。c-erb B-1/EGF-r基因未扩增。然而，在1例子宫内膜腺癌中，发现c-erb B-1/EGF-r基因在该基因的5'区域发生了重排。重排后的c-erb B-1/EGF-r基因的基因组结构与鸡v-erb B癌基因中的结构相似，后者产生一种截短形式的EGF-r。结果表明，c-erb B-2/neu基因的扩增可能在卵巢癌的发病机制中起作用。此外，子宫内膜腺癌中的人类c-erb B-1/EGF-r基因可能通过与鸡v-erb B癌基因相似的机制被激活。
