Kaplan Ibrahim, Bulut Mahmut, Atli Abdullah, Güneş Mehmet, Kaya Mehmet Cemal, Çolpan Leyla
1Department of Biochemistry, Medical Faculty,Dicle University,Diyarbakır,Turkey.
2Department of Psychiatry, Medical Faculty,Dicle University,Diyarbakır,Turkey.
Acta Neuropsychiatr. 2015 Jun;27(3):177-81. doi: 10.1017/neu.2015.5. Epub 2015 Feb 20.
Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein that is widely used as a tumour marker in adenocarcinomas. However, several non-neoplastic conditions, including acute and chronic inflammation and other inflammation-related conditions, are characterised by increased CEA concentrations. Bipolar disorder (BD) ranks seventh among the worldwide burden of non-fatal diseases. Inflammatory biomarkers have been considered as one of the main key pillars of a multifactorial approach for prediction of BD in an at-risk population. BP is accompanied by activation of inflammatory, cell-mediated and negative immunoregulatory cytokines.
We measured the levels of CEA in serum samples from 44 individuals with euthymic BP out-patients and 45 healthy controls. Patients were diagnosed according to the DSM-IV criteria. CEA was measured by an electrochemiluminescence immunoassay.
The mean serum CEA concentration was 2.36±1.52 and 1.77±0.98 µg/l in patients and controls, respectively. CEA levels were significantly increased in euthymic BP patients when compared with controls (p=0.031).
This study suggests that CEA is increased in BD and supports a role for immune activation in the core pathological mechanisms of BP. CEA levels may be a secondary marker for diagnosing BP.
癌胚抗原（CEA）是一种癌胚糖蛋白，在腺癌中广泛用作肿瘤标志物。然而，包括急性和慢性炎症以及其他炎症相关病症在内的几种非肿瘤性疾病，其特征是CEA浓度升高。双相情感障碍（BD）在全球非致命疾病负担中排名第七。炎症生物标志物已被视为在高危人群中预测BD的多因素方法的主要关键支柱之一。双相情感障碍伴有炎症、细胞介导和负性免疫调节细胞因子的激活。
我们测量了44例双相情感障碍门诊缓解期患者和45名健康对照者血清样本中的CEA水平。患者根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准进行诊断。CEA通过电化学发光免疫分析法进行测量。
患者和对照组的血清CEA平均浓度分别为2.36±1.52和1.77±0.98μg/l。与对照组相比，双相情感障碍门诊缓解期患者的CEA水平显著升高（p = 0.031）。
本研究表明双相情感障碍患者的CEA升高，并支持免疫激活在双相情感障碍核心病理机制中的作用。CEA水平可能是诊断双相情感障碍的次要标志物。
