Faraone S V, Young A S, Brown W A
Brockton-West Roxbury VA Medical Center, MA 02401.
Psychiatry Res. 1989 Jun;28(3):315-21. doi: 10.1016/0165-1781(89)90212-6.
For 2 years we assessed clinical state, and plasma neuroleptic and prolactin levels every 6 months in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. Those who had psychotic symptoms at 50% or more of their visits had higher neuroleptic doses, more tardive dyskinesia, and more affective symptoms than the other patients. These groups were not, however, significantly different in their age of onset, years of education, duration of illness, duration of neuroleptic exposure, or negative symptoms.
两年来，我们对105名男性精神分裂症门诊患者的临床状态以及血浆抗精神病药物和催乳素水平进行了评估，每6个月评估一次。这些患者按照临床确定的剂量服用各种抗精神病药物。那些在超过50%的就诊中出现精神病症状的患者，其抗精神病药物剂量更高，迟发性运动障碍更多，情感症状也比其他患者更多。然而，这些组在发病年龄、受教育年限、病程、抗精神病药物暴露时间或阴性症状方面没有显著差异。
