鲍曼不动杆菌CC113及新型单克隆菌株中2类整合子的优先携带情况
Preferential carriage of class 2 integrons in Acinetobacter baumannii CC113 and novel singletons.
作者信息
Ramírez M S, Montaña S, Cassini M, Centrón D
机构信息
Instituto de Microbiología y Parasitología Médica (IMPaM, UBA-CONICET),Facultad de Medicina,Universidad de Buenos Aires,Argentina.
Grupo GEMA,Departamento de Ciencias Básicas,Universidad Nacional de Luján,Luján,Buenos Aires,Argentina & Laboratorio de Biología del Comportamiento,IBYME,Ciudad Autónoma de Buenos Aires,Argentina.
出版信息
Epidemiol Infect. 2015 Oct;143(14):3118-21. doi: 10.1017/S0950268815000060. Epub 2015 Feb 20.
Our understanding of the distribution of integrons associated with multidrug resistance in Acinetobacter baumannii isolates around the world remains incomplete. The association between the class 1 and 2 integron A. baumannii-positive isolates (n = 60), recovered since 1982 from 11 Argentinean hospitals, and the circulating lineages, was investigated. While class 2 integrons were highly significantly associated with clonal lineage CC113B/CC79P (P = 0·009) and novel singletons (P = 0·001), class 1 integrons were found not to be associated with CC109B/CC1P or other lineages. The study reveals a differential distribution of class 2 integrons in lineages, and suggests that the prevalence of intI2 in Argentina is related to the emergence of novel singletons in recent years and to the abundance of CC113B/CC79P, which has been the local dominant lineage for several decades.
我们对世界各地鲍曼不动杆菌分离株中与多重耐药性相关的整合子分布的了解仍不完整。对1982年以来从11家阿根廷医院分离出的60株鲍曼不动杆菌阳性菌株中1类和2类整合子与流行谱系之间的关联进行了研究。虽然2类整合子与克隆谱系CC113B/CC79P（P = 0·009）和新的单克隆菌株（P = 0·001）高度显著相关，但发现1类整合子与CC109B/CC1P或其他谱系无关。该研究揭示了2类整合子在谱系中的差异分布，并表明阿根廷intI2的流行与近年来新的单克隆菌株的出现以及CC113B/CC79P的丰富有关，CC113B/CC79P几十年来一直是当地的主要谱系。
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