Drake Thomas M
Academic Unit of Surgical Oncology, The Medical School, University of Sheffield, Sheffield, S10 2RX, UK,
Neuromolecular Med. 2015 Jun;17(2):147-57. doi: 10.1007/s12017-015-8346-x. Epub 2015 Feb 20.
With the rise of aging populations, new challenges for health care systems are emerging. Degenerative conditions of the central nervous system share a strikingly great deal of similarities, particularly the production and buildup of malfolded proteins. As a result, stress pathways within the endoplasmic reticulum become activated, triggering widespread neuronal apoptosis. New pharmacological compounds targeting this response are emerging as promising treatment strategies. This review examines the current evidence for protein aggregation in neurodegenerative disease states and discusses future mechanisms of therapeutically targeting the endoplasmic reticulum.
随着老龄化人口的增加，医疗保健系统面临着新的挑战。中枢神经系统的退行性疾病有很多显著的相似之处，尤其是错误折叠蛋白质的产生和积累。结果，内质网内的应激途径被激活，引发广泛的神经元凋亡。针对这种反应的新型药理化合物正成为有前景的治疗策略。本文综述了神经退行性疾病状态下蛋白质聚集的现有证据，并讨论了内质网靶向治疗的未来机制。
