水飞蓟素在不同温度下于聚乙二醇400 - 水混合物中的溶解热力学与溶解度
Dissolution thermodynamics and solubility of silymarin in PEG 400-water mixtures at different temperatures.
作者信息
Shakeel Faiyaz, Anwer Md Khalid
机构信息
a Center of Excellence in Biotechnology Research, College of Science, King Saud University , Riyadh , Saudi Arabia .
b Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University , Riyadh , Saudi Arabia , and.
出版信息
Drug Dev Ind Pharm. 2015;41(11):1819-23. doi: 10.3109/03639045.2015.1009914. Epub 2015 Sep 25.
An isothermal method was used to measure the solubility of silymarin in binary polyethylene glycol 400 (PEG 400) + water co-solvent mixtures at temperatures T = 298.15-333.15 K and pressure p = 0.1 MPa. Apelblat and Yalkowsky models were used to correlate experimental solubility data. The mole fraction solubility of silymarin was found to increase with increasing the temperature and mass fraction of PEG 400 in co-solvent mixtures. The root mean square deviations were observed in the range of 0.48-5.32% and 1.50-9.65% for the Apelblat equation and Yalkowsky model, respectively. The highest and lowest mole fraction solubility of silymarin was observed in pure PEG 400 (0.243 at 298.15 K) and water (1.46 × 10(-5) at 298.15 K). Finally, thermodynamic parameters were determined by Van't Hoff and Krug analysis, which indicated an endothermic and spontaneous dissolution of silymarin in all co-solvent mixtures.
采用等温法在温度T = 298.15 - 333.15 K和压力p = 0.1 MPa条件下，测定水飞蓟素在二元聚乙二醇400（PEG 400）+水混合共溶剂中的溶解度。使用Apelblat模型和Yalkowsky模型关联实验溶解度数据。结果表明，水飞蓟素的摩尔分数溶解度随共溶剂混合物中温度和PEG 400质量分数的增加而增大。Apelblat方程和Yalkowsky模型的均方根偏差分别在0.48 - 5.32%和1.50 - 9.65%范围内。水飞蓟素的摩尔分数溶解度在纯PEG 400（298.15 K时为0.243）和水（298.15 K时为1.46×10⁻⁵）中分别观察到最高值和最低值。最后，通过范特霍夫和克鲁格分析确定了热力学参数，结果表明水飞蓟素在所有共溶剂混合物中的溶解过程为吸热且自发过程。
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