阿魏酸在不同（异丙醇+水）混合物中的溶解度和分子相互作用。

Solubility and molecular interactions of ferulic acid in various (isopropanol + water) mixtures.

机构信息

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

出版信息

J Pharm Pharmacol. 2017 Nov;69(11):1485-1494. doi: 10.1111/jphp.12786. Epub 2017 Jul 19.

DOI:10.1111/jphp.12786

PMID:28722130

Abstract

OBJECTIVE

The solubility of an herbal compound ferulic acid (FA) in various (isopropanol (IPA) + water) mixtures was measured and correlated at temperatures 'T = 298.2 K to 318.2 K' and pressure 'p = 0.1 MPa'.

METHODS

The experimental solubilities of FA in mole fraction were determined using a static equilibrium method and correlated with 'Apelblat, Van't Hoff, Yalkowsky and Jouyban-Acree models'.

KEY FINDINGS

The maximum mole fraction solubilities of FA were obtained in neat IPA (2.58 × 10 at T = 318.2 K) followed by minimum in neat water (4.87 × 10 at T = 298.2 K). The activity coefficients of FA in various (IPA + water) mixtures were determined to evaluate the molecular interactions between FA and co solvent mixtures. Strong molecular interactions were seen between FA and neat IPA in comparison with FA and neat water. 'Apparent thermodynamic analysis' indicated an 'endothermic and entropy-driven dissolution' of FA in all (IPA + water) mixtures evaluated.

CONCLUSIONS

Isopropanol was investigated as a good cosolvent in the solubility enhancement of FA in water; therefore, it could be used as solubilizer in solubility enhancement and formulation development of FA.

摘要

目的

测量并关联在温度 'T = 298.2 K 至 318.2 K' 和压力 'p = 0.1 MPa' 下，中草药化合物阿魏酸（FA）在各种（异丙醇（IPA）+水）混合物中的溶解度。

方法

使用静态平衡法测定 FA 的实验摩尔分数溶解度，并与 'Apelblat、Van't Hoff、Yalkowsky 和 Jouyban-Acree 模型' 相关联。

主要发现

FA 的最大摩尔分数溶解度在纯 IPA 中获得（在 T = 318.2 K 时为 2.58×10），其次是在纯水中获得（在 T = 298.2 K 时为 4.87×10）。测定 FA 在各种（IPA+水）混合物中的活度系数，以评估 FA 与共溶剂混合物之间的分子相互作用。与 FA 和纯水相比，FA 与纯 IPA 之间存在强烈的分子相互作用。“明显的热力学分析”表明，FA 在所有评估的（IPA+水）混合物中均为“吸热和熵驱动的溶解”。