语前聋青少年听觉、语言和视觉系统内部及之间的灰质连接性
Grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.
作者信息
Li Wenjing, Li Jianhong, Wang Zhenchang, Li Yong, Liu Zhaohui, Yan Fei, Xian Junfang, He Huiguang
机构信息
College of Electronic and Control Engineering, Beijing University of Technology, Beijing, China.
State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
出版信息
Restor Neurol Neurosci. 2015;33(3):279-90. doi: 10.3233/RNN-140437.
PURPOSE
Previous studies have shown brain reorganizations after early deprivation of auditory sensory. However, changes of grey matter connectivity have not been investigated in prelingually deaf adolescents yet. In the present study, we aimed to investigate changes of grey matter connectivity within and between auditory, language and visual systems in prelingually deaf adolescents.
METHODS
We recruited 16 prelingually deaf adolescents and 16 age-and gender-matched normal controls, and extracted the grey matter volume as the structural characteristic from 14 regions of interest involved in auditory, language or visual processing to investigate the changes of grey matter connectivity within and between auditory, language and visual systems. Sparse inverse covariance estimation (SICE) was utilized to construct grey matter connectivity between these brain regions.
RESULTS
The results show that prelingually deaf adolescents present weaker grey matter connectivity within auditory and visual systems, and connectivity between language and visual systems declined. Notably, significantly increased brain connectivity was found between auditory and visual systems in prelingually deaf adolescents.
CONCLUSIONS
Our results indicate "cross-modal" plasticity after deprivation of the auditory input in prelingually deaf adolescents, especially between auditory and visual systems. Besides, auditory deprivation and visual deficits might affect the connectivity pattern within language and visual systems in prelingually deaf adolescents.
目的
先前的研究表明，早期听觉感觉剥夺后大脑会发生重组。然而，对于语前聋青少年灰质连接性的变化尚未进行研究。在本研究中，我们旨在调查语前聋青少年听觉、语言和视觉系统内部及之间灰质连接性的变化。
方法
我们招募了16名语前聋青少年和16名年龄及性别匹配的正常对照，从参与听觉、语言或视觉处理的14个感兴趣区域提取灰质体积作为结构特征，以研究听觉、语言和视觉系统内部及之间灰质连接性的变化。采用稀疏逆协方差估计（SICE）来构建这些脑区之间的灰质连接性。
结果
结果显示，语前聋青少年在听觉和视觉系统内部的灰质连接性较弱，语言和视觉系统之间的连接性下降。值得注意的是，在语前聋青少年中发现听觉和视觉系统之间的大脑连接性显著增加。
结论
我们的结果表明，语前聋青少年听觉输入剥夺后存在“跨模态”可塑性，尤其是在听觉和视觉系统之间。此外，听觉剥夺和视觉缺陷可能会影响语前聋青少年语言和视觉系统内部的连接模式。
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