Cazavet Alexandre, Alacoque Xavier, Marcheix Bertrand, Chaufour Xavier, Rousseau Herve, Glock Yves, Leobon Bertrand
Department of Cardiovascular Surgery, University Hospital of Toulouse, Toulouse, France
Department of Anesthesia and Intensive Care, University Hospital of Toulouse, Toulouse, France.
Eur J Cardiothorac Surg. 2016 Jan;49(1):134-40. doi: 10.1093/ejcts/ezv024. Epub 2015 Feb 19.
Open arch surgery for aortic arch aneurysm was historically associated with a high risk of postoperative morbi-mortality. Improved operative techniques have now lowered the incidence of these complications but in parallel, hybrid arch procedures have emerged. Nowadays, very little data are available about their mid-term results compared with open surgery.
From January 2002 to January 2014, 46 patients had treatment for an exclusive aortic arch aneurysm including 25 open arch surgeries and 21 type I hybrid arch procedures in our institution. All cases involved arch aneurysms involving at least one carotid artery (Zone 0 and Zone 1). Aneurysms of the distal arch and descending aorta were excluded (Zone 2 and beyond). Results from a retrospective database are reported. There were no patients lost to the follow-up.
There was no significant difference in preoperative comorbidities between the two groups. The incidence of in-hospital mortality was similar at 20% (5/25) for open surgery and 19% (4/21) for hybrid procedure (P = 0.830). The incidence of permanent cerebral neurological deficit was comparable at 17.4% (4/23) for open surgery and 21.1% (4/19) for hybrid procedure (P = 1). Median survival was 109.5 months for open surgery and 56.3 months for hybrid procedure. Freedom from all-cause mortality was 78, 63, 63 and 57% at 1, 3, 5 and 7 years, respectively in the open surgical group. Freedom from all-cause mortality was 74, 55, 46 and 28% at 1, 3, 5 and 7 years, respectively in the hybrid group. Survival rates and incidence of major adverse cardiac and cerebro-vascular event between open surgery and hybrid procedure were not statistically different (P = 0.530 and P = 0.325, respectively). However, incidence of reintervention was in favour of open surgery [14.5 vs 44.8% at 7 years, P = 0.045; 95% confidence interval: (0.06-0.97)].
The type I hybrid arch procedure fails to demonstrate better results compared with open surgery, regarding morbi-mortality at the short- and mid-term follow-up. Moreover, it increases the risk of reintervention. Patients treated by this technique must undergo a closer follow-up because of this risk. Larger randomized studies are needed to better define the exact indications of this therapy.
主动脉弓动脉瘤的开放弓部手术在历史上与术后高病残率和死亡率相关。如今,改进的手术技术已降低了这些并发症的发生率,但与此同时,杂交弓部手术也应运而生。目前,与开放手术相比,关于其中期结果的数据非常少。
2002年1月至2014年1月,在我们机构中,46例患者接受了单纯主动脉弓动脉瘤治疗,其中包括25例开放弓部手术和21例I型杂交弓部手术。所有病例均涉及至少累及一根颈动脉的弓部动脉瘤(0区和1区)。远端弓部和降主动脉的动脉瘤被排除(2区及更远部位)。报告了回顾性数据库的结果。没有患者失访。
两组术前合并症无显著差异。开放手术的院内死亡率为20%(5/25),杂交手术为19%(4/21),两者相似(P = 0.830)。开放手术永久性脑神经系统缺陷的发生率为17.4%(4/23),杂交手术为21.1%(4/19),两者相当(P = 1)。开放手术的中位生存期为109.5个月,杂交手术为56.3个月。开放手术组1、3、5和7年的全因死亡率分别为78%、63%(63%)和57%。杂交手术组1、3、5和7年的全因死亡率分别为74%、55%、46%和28%。开放手术和杂交手术之间的生存率以及主要不良心脑血管事件的发生率无统计学差异(分别为P = 0.530和P = 0.325)。然而,再次干预的发生率有利于开放手术[7年时为14.5%对44.8%,P = 0.045;95%置信区间:(0.06 - 0.97)]。
在短期和中期随访中,就病残率和死亡率而言,I型杂交弓部手术与开放手术相比未能显示出更好的结果。此外,它增加了再次干预的风险。由于这种风险,接受该技术治疗的患者必须接受更密切的随访。需要更大规模的随机研究来更好地确定这种治疗的确切适应症。