Osaki Yusuke, Nodera Hiroyuki, Banzrai Chimeglkham, Endo Sachiko, Takayasu Hirokazu, Mori Atsuko, Shimatani Yoshimitsu, Kaji Ryuji
Department of Neurology, Tokushima University, Tokushima, Japan.
Department of Neurology, Tokushima University, Tokushima, Japan.
Clin Neurophysiol. 2015 Oct;126(10):2033-9. doi: 10.1016/j.clinph.2014.12.025. Epub 2015 Jan 19.
The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability.
Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection ("triple agents"). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored.
Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current.
Anesthetic agents affected responses to long hyperpolarizing currents.
Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents.
本研究旨在探讨麻醉剂对周围神经兴奋性的体内影响。
将正常雄性小鼠通过吸入异氟烷或腹腔注射美托咪定、咪达唑仑和布托啡诺的组合（“三联剂”）进行麻醉。诱导后立即记录尾部感觉神经动作电位并监测其兴奋性。
在两种麻醉方案下，长超极化电流均引起间隔兴奋性变化。与诱导后立即相比，诱导后约30分钟阈值降低更明显。其他兴奋性参数随时间保持稳定。模型提示节间H电导或漏电流的间隔抑制。
麻醉剂影响对长超极化电流的反应。
术中监测期间的轴突兴奋性可能受麻醉剂影响。麻醉状态下间隔兴奋性变化的解读需谨慎，尤其是对于长超极化电流。
