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主动脉瓣置换术中冠状动脉开口受压:一种可避免的并发症。

Coronary ostial compromise in aortic valve replacement: an avoidable complication.

作者信息

Farid Shakil, Page Aravinda, Howell Neil, Goddard Martin, Abu-Omar Yasir, Jenkins David P, Nashef Samer Am

机构信息

Department of Cardiothoracic Surgery, Papworth Hospital NHS Foundation Trust, Cambridge, UK

Department of Cardiothoracic Surgery, Papworth Hospital NHS Foundation Trust, Cambridge, UK.

出版信息

Asian Cardiovasc Thorac Ann. 2015 Jun;23(5):535-42. doi: 10.1177/0218492315573105. Epub 2015 Feb 18.

Abstract

BACKGROUND

We sought to determine the incidence of hospital death due to surgical compromise of the coronary ostia in aortic valve replacement. The mechanism of coronary ostium blockage was also investigated.

METHODS

A retrospective review was conducted of prospectively collected clinical data and autopsy findings in 322 patients who died in hospital after aortic valve replacement with or without concomitant procedures in a single institution from January 1998 to March 2013.

RESULTS

Over the 15-year period, more than 17 surgeons performed 7507 aortic valve replacements with or without other procedures. The mean age of the patients was 70.8 ± 11.78 years and 63% were male. Bioprosthetic valves were used in 75%, mechanical valves in 24.7%, and homografts in only 0.3%. Early mortality for all patients (combined, emergency, and redo procedures) was 4.29% (mean logistic EuroSCORE 10.7). There were 322 deaths after procedures involving the aortic valve. Autopsy examinations were carried out in all patients and showed that 3.4% (n = 11) of deaths were at least partly attributed to encroachment on one or both coronary ostia. Causes of ostial compromise included the valve sutures, the valve sewing ring, and the aortotomy suture line.

CONCLUSIONS

Coronary ostial compromise in aortic valve replacement is a very rare but real problem occurring in at least 0.15% of aortic valve replacements and contributing to or directly causing one in every 29 aortic valve replacement deaths. Surgeons should have a high level of awareness of the risk of this rare but fatal and avoidable complication.

摘要

背景

我们试图确定在主动脉瓣置换术中因冠状动脉开口手术损伤导致的医院死亡发生率。同时也对冠状动脉开口阻塞的机制进行了研究。

方法

对1998年1月至2013年3月在单一机构接受主动脉瓣置换术(无论是否伴有其他手术)后死亡的322例患者的前瞻性收集的临床数据和尸检结果进行回顾性分析。

结果

在这15年期间,超过17名外科医生进行了7507例主动脉瓣置换术(无论是否伴有其他手术)。患者的平均年龄为70.8±11.78岁,63%为男性。75%的患者使用生物瓣膜,24.7%使用机械瓣膜,仅0.3%使用同种异体移植物。所有患者(包括初次、急诊和再次手术)的早期死亡率为4.29%(平均逻辑欧洲心脏手术风险评估系统评分为10.7)。在涉及主动脉瓣的手术后有322例死亡。对所有患者进行了尸检,结果显示3.4%(n = 11)的死亡至少部分归因于一个或两个冠状动脉开口受到侵犯。开口受损的原因包括瓣膜缝线、瓣膜缝合环和主动脉切开缝合线。

结论

主动脉瓣置换术中冠状动脉开口受损是一个非常罕见但确实存在的问题,至少发生在0.15%的主动脉瓣置换术中,并且在每29例主动脉瓣置换术死亡中占1例,是导致死亡的原因之一或直接导致死亡。外科医生应高度意识到这种罕见但致命且可避免的并发症的风险。

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