The pathology of the amyloid A4 precursor of Alzheimer's disease.
作者信息
Masters C L, Beyreuther K T
机构信息
Department of Pathology, University of Melbourne, Australia.
出版信息
Ann Med. 1989;21(2):89-90. doi: 10.3109/07853898909149190.
PMID:2569883
Abstract
The A4 amyloid protein is the major subunit present in the amyloid of Alzheimer's disease. It is derived by proteolytic cleavage from a larger precursor (PreA4) which is a neuronal membrane glycoprotein. Whereas in Down's syndrome, over-expression of the gene coding for PreA4 is likely to be responsible for the premature development of cerebral amyloidosis, a similar mechanism is yet to be demonstrated in Alzheimer's disease.
摘要
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