激素避孕药与脑静脉血栓形成风险：一项系统评价与荟萃分析。
Hormonal contraceptives and cerebral venous thrombosis risk: a systematic review and meta-analysis.
作者信息
Amoozegar Farnaz, Ronksley Paul E, Sauve Reg, Menon Bijoy K
机构信息
Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada.
Department of Clinical Epidemiology, Ottawa Hospital Research Institute , Ottawa, ON , Canada.
出版信息
Front Neurol. 2015 Feb 2;6:7. doi: 10.3389/fneur.2015.00007. eCollection 2015.
OBJECTIVES
Use of oral contraceptive pills (OCP) increases the risk of cerebral venous sinus thrombosis (CVST). Whether this risk varies by type, duration, and other forms of hormonal contraceptives is largely unknown. This systematic review and meta-analysis update the current state of knowledge.
METHODS
We performed a search to identify all published studies on the association between hormonal contraceptive use and risk of CVST in women aged 15-50 years.
RESULTS
Of 861 studies reviewed, 11 were included. The pooled odds of developing CVST in women aged 15-50 years taking OCPs was 7.59 times higher compared to women not taking OCPs (OR = 7.59, 95% CI 3.82-15.09). Data are insufficient to make conclusions about duration of use and other forms of hormonal contraceptives.
CONCLUSION
Oral contraceptive pills use increases the risk of developing CVST in women of reproductive age. Future studies are required to determine if duration and type of hormonal contraceptives modify this risk.
目的
口服避孕药（OCP）的使用会增加脑静脉窦血栓形成（CVST）的风险。这种风险是否因避孕药类型、使用时长以及其他形式的激素避孕药而有所不同，目前很大程度上尚不清楚。本系统评价和荟萃分析更新了当前的知识状况。
方法
我们进行了一项检索，以确定所有已发表的关于15至50岁女性使用激素避孕药与CVST风险之间关联的研究。
结果
在审查的861项研究中，纳入了11项。与未服用OCP的女性相比，15至50岁服用OCP的女性发生CVST的合并比值高出7.59倍（OR = 7.59，95% CI 3.82 - 15.09）。关于使用时长和其他形式的激素避孕药的数据不足以得出结论。
结论
口服避孕药的使用会增加育龄女性发生CVST的风险。未来需要开展研究，以确定激素避孕药的使用时长和类型是否会改变这种风险。
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