WIT 引领白血病治疗新路径。
A new path to leukemia with WIT.
机构信息
Center for Genomic Regulation, C/Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain; Pompeu Fabra University, Plaça de la Mercè, 10, 08002 Barcelona, Spain.
出版信息
Mol Cell. 2015 Feb 19;57(4):573-574. doi: 10.1016/j.molcel.2015.02.005.
PMID:25699704
Abstract
In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.
摘要
在本期中，Wang 等人，2015 年描述了 WT1 将 TET2 募集到 DNA 上，这是与急性髓系白血病（AML）发展相关的新调控途径的一个重要特征。该途径由 WT1、IDH1/2 和 TET2（WIT）基因组成，三个基因的独特突变诱导髓系细胞增殖。
Zotero 插件