Northridge D B, Jardine A G, Alabaster C T, Barclay P L, Connell J M, Dargie H J, Dilly S G, Findlay I N, Lever A F, Samuels G M
Department of Cardiology, Western Infirmary, Glasgow.
Lancet. 1989 Sep 9;2(8663):591-3. doi: 10.1016/s0140-6736(89)90714-9.
UK 69 578 is a competitive inhibitor of endopeptidase 24.11 (the enzyme that degrades atrial natriuretic factor) in vitro. In vivo, UK 69 578 has renal and cardiovascular effects similar to low-dose atrial natriuretic factor infusion, and may be a useful agent in hypertension and heart failure.
UK 69 578在体外是内肽酶24.11（降解心房利钠因子的酶）的竞争性抑制剂。在体内，UK 69 578具有与低剂量输注心房利钠因子相似的肾脏和心血管效应，可能是治疗高血压和心力衰竭的有效药物。
