酶转化以调节小分子之间的配体-受体相互作用。
Enzyme transformation to modulate the ligand-receptor interactions between small molecules.
作者信息
Shi Junfeng, Du Xuewen, Yuan Dan, Haburcak Richard, Wu Dongdong, Zhou Ning, Xu Bing
机构信息
Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.
出版信息
Chem Commun (Camb). 2015 Mar 21;51(23):4899-901. doi: 10.1039/c4cc10374b.
Abstract
Enzymatic transformation is a fundamental process to control ligand-receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand-receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand-receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand-receptor interactions of small molecules is able to affect the fate of cells.
摘要
酶促转化是控制细胞中蛋白质间配体 - 受体相互作用以进行信号转导的基本过程。在此，我们报道了小分子的酶促转化调节配体 - 受体相互作用的首个实例，其中酶促反应将配体 - 受体结合的化学计量比从1∶1改变为1∶2。我们还表明，这种酶促转化与小分子配体 - 受体相互作用的独特整合能够影响细胞命运。
相似文献
1
Enzyme transformation to modulate the ligand-receptor interactions between small molecules.
Chem Commun (Camb). 2015 Mar 21;51(23):4899-901. doi: 10.1039/c4cc10374b.
2
Protein structural change upon ligand binding correlates with enzymatic reaction mechanism.
J Mol Biol. 2008 Jun 6;379(3):397-401. doi: 10.1016/j.jmb.2008.04.019. Epub 2008 Apr 11.
3
Periplasmic binding proteins: a versatile superfamily for protein engineering.
Curr Opin Struct Biol. 2004 Aug;14(4):495-504. doi: 10.1016/j.sbi.2004.07.004.
4
Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes.
Angew Chem Int Ed Engl. 2004 Dec 10;43(48):6596-616. doi: 10.1002/anie.200300644.
5
Interaction model based on local protein substructures generalizes to the entire structural enzyme-ligand space.
J Chem Inf Model. 2008 Nov;48(11):2278-88. doi: 10.1021/ci800200e.
6
Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules.
J Am Chem Soc. 2016 Nov 30;138(47):15397-15404. doi: 10.1021/jacs.6b07677. Epub 2016 Nov 15.
7
Enzymatic hydrogelation of small molecules.
Acc Chem Res. 2008 Feb;41(2):315-26. doi: 10.1021/ar7001914. Epub 2008 Jan 19.
8
[Receptor-enzyme interactions. Kinetic characteristics].
Biokhimiia. 1988 Oct;53(10):1677-83.
9
A Review on the Receptor-ligand Molecular Interactions in the Nicotinic Receptor Signaling Systems.
Pak J Biol Sci. 2018;21(2):51-66. doi: 10.3923/pjbs.2018.51.66.
10
Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila.
J Cell Sci. 1999 Oct;112 ( Pt 19):3289-97. doi: 10.1242/jcs.112.19.3289.
引用本文的文献
1
Applications of self-assembled peptide hydrogels in anti-tumor therapy.
Nanoscale Adv. 2024 Apr 30;6(12):2993-3008. doi: 10.1039/d4na00172a. eCollection 2024 Jun 11.
2
Supramolecular biofunctional materials.
Biomaterials. 2017 Jun;129:1-27. doi: 10.1016/j.biomaterials.2017.03.014. Epub 2017 Mar 12.
3
Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules.
J Am Chem Soc. 2016 Nov 30;138(47):15397-15404. doi: 10.1021/jacs.6b07677. Epub 2016 Nov 15.
4
The Enzyme-instructed assembly of the core of yeast prion Sup35 to form supramolecular hydrogels.
J Mater Chem B. 2016 Feb 21;4(7):1318-1323. doi: 10.1039/C5TB02346G. Epub 2016 Jan 11.
5
Nanoscale Assemblies of Small Molecules Control the Fate of Cells.
Nano Today. 2015 Oct;10(5):615-630. doi: 10.1016/j.nantod.2015.09.001. Epub 2015 Oct 20.
6
Supramolecular Detoxification of Neurotoxic Nanofibrils of Small Molecules via Morphological Switch.
Bioconjug Chem. 2015 Sep 16;26(9):1879-83. doi: 10.1021/acs.bioconjchem.5b00356. Epub 2015 Aug 12.
本文引用的文献
1
The bioactivity of composite Fmoc-RGDS-collagen gels.
Biomater Sci. 2014 Sep 29;2(9):1222-1229. doi: 10.1039/c4bm00121d. Epub 2014 Jun 4.
2
Controlling cancer cell fate using localized biocatalytic self-assembly of an aromatic carbohydrate amphiphile.
J Am Chem Soc. 2015 Jan 21;137(2):576-9. doi: 10.1021/ja5111893. Epub 2015 Jan 8.
3
Ligand-receptor interaction catalyzes the aggregation of small molecules to induce cell necroptosis.
J Am Chem Soc. 2015 Jan 14;137(1):26-9. doi: 10.1021/ja5100417. Epub 2014 Dec 26.
4
Cancer cell death induced by the intracellular self-assembly of an enzyme-responsive supramolecular gelator.
J Am Chem Soc. 2015 Jan 21;137(2):770-5. doi: 10.1021/ja510156v. Epub 2015 Jan 5.
5
Enzymatic transformation of phosphate decorated magnetic nanoparticles for selectively sorting and inhibiting cancer cells.
Bioconjug Chem. 2014 Dec 17;25(12):2129-33. doi: 10.1021/bc500516g. Epub 2014 Dec 4.
6
Unraveling the mechanism of cell death induced by chemical fibrils.
Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28.
7
D-amino acids modulate the cellular response of enzymatic-instructed supramolecular nanofibers of small peptides.
Biomacromolecules. 2014 Oct 13;15(10):3559-68. doi: 10.1021/bm5010355. Epub 2014 Sep 17.
8
Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.
J Biol Chem. 2014 Oct 17;289(42):29208-18. doi: 10.1074/jbc.M114.600288. Epub 2014 Aug 25.
9
Pericellular hydrogel/nanonets inhibit cancer cells.
Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8104-7. doi: 10.1002/anie.201402216. Epub 2014 May 12.
10
Probing secondary interactions in biomolecular recognition by dynamic combinatorial chemistry.
Chem Commun (Camb). 2014 Jun 4;50(44):5810-25. doi: 10.1039/c4cc00263f.
Zotero 插件