Gold Marielle C, Napier Ruth J, Lewinsohn David M
Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA; VA Portland Health Care System (VAPORHCS), Portland, OR, USA; Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.
Immunol Rev. 2015 Mar;264(1):154-66. doi: 10.1111/imr.12271.
The intracellular pathogen Mycobacterium tuberculosis (Mtb) and its human host have long co-evolved. Although the host cellular immune response is critical to the control of the bacterium information on the specific contribution of different immune cell subsets in humans is incomplete. Mucosal associated invariant T (MAIT) cells are a prevalent and unique T-cell population in humans with the capacity to detect intracellular infection with bacteria including Mtb. MAIT cells detect bacterially derived metabolites presented by the evolutionarily conserved major histocompatibility complex-like molecule MR1. Here, we review recent advances in our understanding of this T-cell subset and address the potential roles for MR1-restricted T cells in the control, diagnosis, and therapy of tuberculosis.
细胞内病原体结核分枝杆菌(Mtb)与其人类宿主长期共同进化。尽管宿主细胞免疫反应对于控制该细菌至关重要,但关于人类不同免疫细胞亚群的具体贡献的信息并不完整。黏膜相关恒定T(MAIT)细胞是人类中普遍且独特的T细胞群体,具有检测包括Mtb在内的细菌细胞内感染的能力。MAIT细胞检测由进化上保守的主要组织相容性复合体样分子MR1呈递的细菌衍生代谢物。在此,我们综述了我们对这一T细胞亚群理解的最新进展,并探讨了MR1限制性T细胞在结核病控制、诊断和治疗中的潜在作用。